Therapy Failure and Resistance Mechanism in Eyelid and Ocular Surface Tumors

Xiaojun Ju, Piotr Gaca, Wanlin Fan, Alexander C. Rokohl, Yongwei Guo, Philomena A. Wawer Matos, Steffen Emmert, Vinodh Kakkassery, Ludwig M. Heindl

1 Citation (Scopus)


Malignant tumors of the eyelids and ocular surface are common ocular malignancies. At present, surgical treatment is mostly the first choice for these types of tumors. However, postoperative tumor recurrence and metastasis are still regarded as failures in the treatment of such malignancies. Based on this, malignant tumors of the eyelid and ocular surface are sometimes accompanied by local adjuvant chemotherapy and systemic chemotherapy to treat patients with relapse, invasion of adjacent tissues, and systemic metastases. Still, drug resistance greatly affects the treatment effect. This review lists several mechanisms of recurrence and metastasis of ocular surface and eyelid tumors after surgery, as well as mechanisms that may lead to non-surgical treatment or drug resistance.

Original languageEnglish
Issue numberS1
Pages (from-to)21-38
Number of pages18
Publication statusPublished - 25.08.2022

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)
  • Centers: University Cancer Center Schleswig-Holstein (UCCSH)

DFG Research Classification Scheme

  • 206-11 Ophthalmology
  • 205-14 Haematology, Oncology

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