The value of FDG-PET and bone scintigraphy with SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible

S. G. Hakim; C. W.R. Bruecker; H. Ch Jacobsen; D. Hermes; I. Lauer; S. Eckerle; A. Froehlich; P. Sieg

doi:10.1016/j.ijom.2006.03.029

The value of FDG-PET and bone scintigraphy with SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible

S. G. Hakim^*, C. W.R. Bruecker, H. Ch Jacobsen, D. Hermes, I. Lauer, S. Eckerle, A. Froehlich, P. Sieg

^*Corresponding author for this work

University Hospital of Luebeck

Abstract

Objective: To appraise the value of FDG-PET and bone scintigraphy using SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible (COM). Methods: In a prospective study the pattern of tracer uptake was investigated using 2 diagnostic methods in 42 patients. Results were compared with histology and radiographs as well as clinical and laboratory parameters. Results: The use of FDG-PET in the primary diagnosis of COM resulted in a sensitivity of 64% and a specificity of 77.7%. The sensitivity of SPECT was 84% and the specificity 33.3%. During the follow-up period of these patients the sensitivity of SPECT increased to 93.7%, while the specificity decreased (6.6%). The sensitivity and specificity of FDG-PET for this follow-up group were 62.5 and 80%, respectively. Conclusion: Because of its high sensitivity, SPECT is vastly superior to other diagnostic methods in initiating treatment. In the follow-up period it might be replaced by FDG-PET, which reflects the disease course better and indicates the time of clinical remission.

Original language	English
Journal	International Journal of Oral and Maxillofacial Surgery
Volume	35
Issue number	9
Pages (from-to)	809-816
Number of pages	8
ISSN	0901-5027
DOIs	https://doi.org/10.1016/j.ijom.2006.03.029
Publication status	Published - 09.2006

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Hakim, S. G., Bruecker, C. W. R., Jacobsen, H. C., Hermes, D., Lauer, I., Eckerle, S., Froehlich, A., & Sieg, P. (2006). The value of FDG-PET and bone scintigraphy with SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible. International Journal of Oral and Maxillofacial Surgery, 35(9), 809-816. https://doi.org/10.1016/j.ijom.2006.03.029

@article{f6f4912801d246acb746e3165fb12093,

title = "The value of FDG-PET and bone scintigraphy with SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible",

abstract = "Objective: To appraise the value of FDG-PET and bone scintigraphy using SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible (COM). Methods: In a prospective study the pattern of tracer uptake was investigated using 2 diagnostic methods in 42 patients. Results were compared with histology and radiographs as well as clinical and laboratory parameters. Results: The use of FDG-PET in the primary diagnosis of COM resulted in a sensitivity of 64\% and a specificity of 77.7\%. The sensitivity of SPECT was 84\% and the specificity 33.3\%. During the follow-up period of these patients the sensitivity of SPECT increased to 93.7\%, while the specificity decreased (6.6\%). The sensitivity and specificity of FDG-PET for this follow-up group were 62.5 and 80\%, respectively. Conclusion: Because of its high sensitivity, SPECT is vastly superior to other diagnostic methods in initiating treatment. In the follow-up period it might be replaced by FDG-PET, which reflects the disease course better and indicates the time of clinical remission.",

author = "Hakim, \{S. G.\} and Bruecker, \{C. W.R.\} and Jacobsen, \{H. Ch\} and D. Hermes and I. Lauer and S. Eckerle and A. Froehlich and P. Sieg",

year = "2006",

month = sep,

doi = "10.1016/j.ijom.2006.03.029",

language = "English",

volume = "35",

pages = "809--816",

journal = "International Journal of Oral and Maxillofacial Surgery",

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}

Hakim, SG, Bruecker, CWR, Jacobsen, HC, Hermes, D, Lauer, I, Eckerle, S, Froehlich, A & Sieg, P 2006, 'The value of FDG-PET and bone scintigraphy with SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible', International Journal of Oral and Maxillofacial Surgery, vol. 35, no. 9, pp. 809-816. https://doi.org/10.1016/j.ijom.2006.03.029

The value of FDG-PET and bone scintigraphy with SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible. / Hakim, S. G.; Bruecker, C. W.R.; Jacobsen, H. Ch et al.
In: International Journal of Oral and Maxillofacial Surgery, Vol. 35, No. 9, 09.2006, p. 809-816.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - The value of FDG-PET and bone scintigraphy with SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible

AU - Hakim, S. G.

AU - Bruecker, C. W.R.

AU - Jacobsen, H. Ch

AU - Hermes, D.

AU - Lauer, I.

AU - Eckerle, S.

AU - Froehlich, A.

AU - Sieg, P.

PY - 2006/9

Y1 - 2006/9

N2 - Objective: To appraise the value of FDG-PET and bone scintigraphy using SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible (COM). Methods: In a prospective study the pattern of tracer uptake was investigated using 2 diagnostic methods in 42 patients. Results were compared with histology and radiographs as well as clinical and laboratory parameters. Results: The use of FDG-PET in the primary diagnosis of COM resulted in a sensitivity of 64% and a specificity of 77.7%. The sensitivity of SPECT was 84% and the specificity 33.3%. During the follow-up period of these patients the sensitivity of SPECT increased to 93.7%, while the specificity decreased (6.6%). The sensitivity and specificity of FDG-PET for this follow-up group were 62.5 and 80%, respectively. Conclusion: Because of its high sensitivity, SPECT is vastly superior to other diagnostic methods in initiating treatment. In the follow-up period it might be replaced by FDG-PET, which reflects the disease course better and indicates the time of clinical remission.

AB - Objective: To appraise the value of FDG-PET and bone scintigraphy using SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible (COM). Methods: In a prospective study the pattern of tracer uptake was investigated using 2 diagnostic methods in 42 patients. Results were compared with histology and radiographs as well as clinical and laboratory parameters. Results: The use of FDG-PET in the primary diagnosis of COM resulted in a sensitivity of 64% and a specificity of 77.7%. The sensitivity of SPECT was 84% and the specificity 33.3%. During the follow-up period of these patients the sensitivity of SPECT increased to 93.7%, while the specificity decreased (6.6%). The sensitivity and specificity of FDG-PET for this follow-up group were 62.5 and 80%, respectively. Conclusion: Because of its high sensitivity, SPECT is vastly superior to other diagnostic methods in initiating treatment. In the follow-up period it might be replaced by FDG-PET, which reflects the disease course better and indicates the time of clinical remission.

UR - https://www.scopus.com/pages/publications/33746084116

U2 - 10.1016/j.ijom.2006.03.029

DO - 10.1016/j.ijom.2006.03.029

M3 - Journal articles

C2 - 16829036

AN - SCOPUS:33746084116

SN - 0901-5027

VL - 35

SP - 809

EP - 816

JO - International Journal of Oral and Maxillofacial Surgery

JF - International Journal of Oral and Maxillofacial Surgery

IS - 9

ER -

The value of FDG-PET and bone scintigraphy with SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible

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