The use of sequential designs in genome scans for asthma susceptibility loci with affected sib pairs

I. R. Böddeker, H. H. Müller, R. Kress, F. Geller, A. Ziegler*, H. Schafer

*Corresponding author for this work
3 Citations (Scopus)

Abstract

We use optimized group sequential study designs to analyze data from two genome scans (German and CSGA) for asthma susceptibility loci with affected sib pairs from Genetic Analysis Workshop (GAW) 12. Results are compared with those from a fixed sample design and the sequential probability ratio test (SPRT). The SPRT does not reach significance at any position. Using the fixed sample design, evidence for linkage is found on chromosomes 6 and 9 in the German and on chromosome 1 in the CSGA scan. The group sequential designs identify the same regions on chromosomes 1 and 6 with a reduced sample size.

Original languageEnglish
JournalGenetic Epidemiology
Volume21
Issue numberSUPPL. 1
Pages (from-to)S49-S54
ISSN0741-0395
DOIs
Publication statusPublished - 2001

Fingerprint

Dive into the research topics of 'The use of sequential designs in genome scans for asthma susceptibility loci with affected sib pairs'. Together they form a unique fingerprint.

Cite this