The Three‐Dimensional Structure of Hammerhead Ribozymes

Georg Sczakiel*

*Corresponding author for this work
3 Citations (Scopus)


Two methods—one result: Through fluorescence energy transfer measurements and an X‐ray structure analysis on ribozyme–substrate complexes, the groups of Eckstein and McKay independently arrived at a largely consistent structural model for hammerhead ribozymes. Three helices are arranged in a stretched Y shape (see picture) and are stabilized by unusual interactions besides the Watson‐Crick base pairing. (Figure Presented.)

Original languageEnglish
JournalAngewandte Chemie International Edition in English
Issue number6
Pages (from-to)643-645
Number of pages3
Publication statusPublished - 31.03.1995


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