The Telomeric Complex and Metabolic Disease

Henriette Kirchner; Fozia Shaheen; Hannes Kalscheuer; Sebastian M. Schmid; Henrik Oster; Hendrik Lehnert

doi:10.3390/genes8070176

The Telomeric Complex and Metabolic Disease

Henriette Kirchner, Fozia Shaheen, Hannes Kalscheuer, Sebastian M. Schmid, Henrik Oster, Hendrik Lehnert^*

^*Corresponding author for this work

Stratlab Ltd.

44 Citations (Scopus)

Abstract

The attrition of telomeres is believed to be a key event not only in mammalian aging, but also in disturbed nutrient sensing, which could lead to numerous metabolic dysfunctions. The current debate focuses mainly on the question whether telomere shortening, e.g., as a heritable trait, may act as a cause or rather represents a consequence of such chronic diseases. This review discusses the damaging events that ultimately may lead or contribute to telomere shortening and can be associated with metabolic diseases.

Original language	English
Article number	176
Journal	Genes
Volume	8
Issue number	7
DOIs	https://doi.org/10.3390/genes8070176
Publication status	Published - 07.07.2017

Funding

This work was supported bv the Deutsche Forschungsgemeinschaft (Emmy-Noether Program KI1887/2-1; SFB-134; GRK-1957).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 8 Decent Work and Economic Growth
SDG 10 Reduced Inequalities

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.3390/genes8070176

Cite this

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AU - Lehnert, Hendrik

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AB - The attrition of telomeres is believed to be a key event not only in mammalian aging, but also in disturbed nutrient sensing, which could lead to numerous metabolic dysfunctions. The current debate focuses mainly on the question whether telomere shortening, e.g., as a heritable trait, may act as a cause or rather represents a consequence of such chronic diseases. This review discusses the damaging events that ultimately may lead or contribute to telomere shortening and can be associated with metabolic diseases.

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The Telomeric Complex and Metabolic Disease

Abstract

Funding

UN SDGs

Research Areas and Centers

Access to Document

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