TY - JOUR
T1 - The Telomeric Complex and Metabolic Disease
AU - Kirchner, Henriette
AU - Shaheen, Fozia
AU - Kalscheuer, Hannes
AU - Schmid, Sebastian M.
AU - Oster, Henrik
AU - Lehnert, Hendrik
PY - 2017/7/7
Y1 - 2017/7/7
N2 - The attrition of telomeres is believed to be a key event not only in mammalian aging, but also in disturbed nutrient sensing, which could lead to numerous metabolic dysfunctions. The current debate focuses mainly on the question whether telomere shortening, e.g., as a heritable trait, may act as a cause or rather represents a consequence of such chronic diseases. This review discusses the damaging events that ultimately may lead or contribute to telomere shortening and can be associated with metabolic diseases.
AB - The attrition of telomeres is believed to be a key event not only in mammalian aging, but also in disturbed nutrient sensing, which could lead to numerous metabolic dysfunctions. The current debate focuses mainly on the question whether telomere shortening, e.g., as a heritable trait, may act as a cause or rather represents a consequence of such chronic diseases. This review discusses the damaging events that ultimately may lead or contribute to telomere shortening and can be associated with metabolic diseases.
UR - http://www.scopus.com/inward/record.url?scp=85023755395&partnerID=8YFLogxK
U2 - 10.3390/genes8070176
DO - 10.3390/genes8070176
M3 - Scientific review articles
C2 - 28686177
AN - SCOPUS:85023755395
VL - 8
JO - Genes
JF - Genes
IS - 7
M1 - 176
ER -
