The SARS-CoV-2 main protease M^pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

Jan Wenzel, Josephine Lampe, Helge Müller-Fielitz, Raphael Schuster, Marietta Zille, Kristin Müller, Markus Krohn, Jakob Körbelin, Linlin Zhang, Ümit Özorhan, Vanessa Neve, Julian U.G. Wagner, Denisa Bojkova, Mariana Shumliakivska, Yun Jiang, Anke Fähnrich, Fabian Ott, Valentin Sencio, Cyril Robil, Susanne PfefferleFlorent Sauve, Caio Fernando Ferreira Coêlho, Jonas Franz, Frauke Spiecker, Beate Lembrich, Sonja Binder, Nina Feller, Peter König, Hauke Busch, Ludovic Collin, Roberto Villaseñor, Olaf Jöhren, Hermann C. Altmeppen, Manolis Pasparakis, Stefanie Dimmeler, Jindrich Cinatl, Klaus Püschel, Matija Zelic, Dimitry Ofengeim, Christine Stadelmann, François Trottein, Ruben Nogueiras, Rolf Hilgenfeld, Markus Glatzel, Vincent Prevot, Markus Schwaninger^*

^*Corresponding author for this work

Institute of Experimental and Clinical Pharmacology and Toxicology
Institute of Medical and Marine Biotechnology
Institute of Biochemistry
Institute of Experimental Dermatology
Institute of Anatomy
Clinic of Dermatology, Allergology and Venerology

Charite - Universitatsmedizin Berlin
Johann Wolfgang Goethe-University
Université Lille-Nord de France
University Hospital Hamburg-Eppendorf
Georg August University Göttingen
Max Planck Institute
Pharma Research and Early Development (pRED)
University of Cologne
Sanofi S.A.
University Santiago de Compostela

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The SARS-CoV-2 main protease M^pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

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Medicine and Dentistry

The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

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Medicine and Dentistry

The SARS-CoV-2 main protease M^pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells