TY - JOUR
T1 - The role of the anterior insula in social norm compliance and enforcement: Evidence from coordinate-based and functional connectivity meta-analyses
AU - Bellucci, Gabriele
AU - Feng, Chunliang
AU - Camilleri, Julia
AU - Eickhoff, Simon B.
AU - Krueger, Frank
N1 - Funding Information:
This work was supported by the German Federal Ministry of Education and Research ( P-57191936 to F. K.), the National Institute of Mental Health ( R01-MH074457 ), the Helmholtz Portfolio Theme “Supercomputing and Modelling for the Human Brain” , the European Union Seventh Framework Program (FP7/2007-2013) under grant agreement no. 7202070 (to S. B. E.), the National Postdoctoral Program for Innovative Talents under grant agreement no. BX201600019 (to C. F.), and the China Postdoctoral Science Foundation under grant agreement no. 2017M610055 (to C.F.).
Publisher Copyright:
© 2018
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2018/9
Y1 - 2018/9
N2 - Economic games —trust (TG) and ultimatum game (UG)— combined with fMRI have shown the importance of the anterior insula (AI) in social normative behaviors. However, whether different AI subregions are engaged in different cognitive and affective processes for social norm compliance and norm enforcement during social exchange remains elusive. Here, we investigated the role of the dorsal AI (dAI) and ventral AI (vAI), combining a coordinate-based meta-analysis of fMRI studies using the TG and UG with meta-analytic task-based and task-free connectivity analyses. Our findings showed that the right dAI and vAI were the only common brain regions consistently activated across games. These clusters were part of two functionally distinguishable connectivity networks associated with cognitive (dAI) and emotional (vAI) processes. In conclusion, we propose that dAI mediates cognitive processes that generate expectancy for norm compliance, whereas vAI mediates aversive feelings that generate motivation to norm enforcement. The identified functional differentiation of the right AI in the social domain contributes to a better understanding of its role in basic and clinical neuroscience.
AB - Economic games —trust (TG) and ultimatum game (UG)— combined with fMRI have shown the importance of the anterior insula (AI) in social normative behaviors. However, whether different AI subregions are engaged in different cognitive and affective processes for social norm compliance and norm enforcement during social exchange remains elusive. Here, we investigated the role of the dorsal AI (dAI) and ventral AI (vAI), combining a coordinate-based meta-analysis of fMRI studies using the TG and UG with meta-analytic task-based and task-free connectivity analyses. Our findings showed that the right dAI and vAI were the only common brain regions consistently activated across games. These clusters were part of two functionally distinguishable connectivity networks associated with cognitive (dAI) and emotional (vAI) processes. In conclusion, we propose that dAI mediates cognitive processes that generate expectancy for norm compliance, whereas vAI mediates aversive feelings that generate motivation to norm enforcement. The identified functional differentiation of the right AI in the social domain contributes to a better understanding of its role in basic and clinical neuroscience.
UR - http://www.scopus.com/inward/record.url?scp=85049854184&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2018.06.024
DO - 10.1016/j.neubiorev.2018.06.024
M3 - Scientific review articles
C2 - 29958872
AN - SCOPUS:85049854184
SN - 0149-7634
VL - 92
SP - 378
EP - 389
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -
