TY - JOUR
T1 - The Role of Tanycytes in the Hypothalamus-Pituitary-Thyroid Axis and the Possibilities for Their Genetic Manipulation
AU - Müller-Fielitz, Helge
AU - Schwaninger, Markus
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Thyroid hormone (TH) regulation is important for development, energy homeostasis, heart function, and bone formation. To control the effects of TH in target organs, the hypothalamus-pituitary-thyroid (HPT) axis and the tissue-specific availability of TH are highly regulated by negative feedback. To exert a central feedback, TH must enter the brain via specific transport mechanisms and cross the blood-brain barrier. Here, tanycytes, which are located in the ventral walls of the 3 rd ventricle in the mediobasal hypothalamus (MBH), function as gatekeepers. Tanycytes are able to transport, sense, and modify the release of hormones of the HPT axis and are involved in feedback regulation. In this review, we focus on the relevance of tanycytes in thyrotropin-releasing hormone (TRH) release and review available genetic tools to investigate the physiological functions of these cells.
AB - Thyroid hormone (TH) regulation is important for development, energy homeostasis, heart function, and bone formation. To control the effects of TH in target organs, the hypothalamus-pituitary-thyroid (HPT) axis and the tissue-specific availability of TH are highly regulated by negative feedback. To exert a central feedback, TH must enter the brain via specific transport mechanisms and cross the blood-brain barrier. Here, tanycytes, which are located in the ventral walls of the 3 rd ventricle in the mediobasal hypothalamus (MBH), function as gatekeepers. Tanycytes are able to transport, sense, and modify the release of hormones of the HPT axis and are involved in feedback regulation. In this review, we focus on the relevance of tanycytes in thyrotropin-releasing hormone (TRH) release and review available genetic tools to investigate the physiological functions of these cells.
UR - http://www.scopus.com/inward/record.url?scp=85086681425&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/0bcd7ecc-a6c6-3742-b973-2bdfd6dc8d77/
U2 - 10.1055/a-1065-1855
DO - 10.1055/a-1065-1855
M3 - Scientific review articles
C2 - 31860118
AN - SCOPUS:85086681425
SN - 0947-7349
VL - 128
SP - 388
EP - 394
JO - Experimental and Clinical Endocrinology and Diabetes
JF - Experimental and Clinical Endocrinology and Diabetes
IS - 6-7
ER -
