The role of long-lived plasma cells in autoimmunity review

Sergio Arce; Giuliana Cassese; Anja Hauser; Thomas Dörner; Marcus Odendahl; Rudi Manz; Andreas Radbruch; Falk Hiepe

doi:10.1078/0171-2985-00204

The role of long-lived plasma cells in autoimmunity review

Sergio Arce, Giuliana Cassese, Anja Hauser, Thomas Dörner, Marcus Odendahl, Rudi Manz, Andreas Radbruch, Falk Hiepe

Institute of Systemic Inflamation Research

Charite - Universitatsmedizin Berlin

18 Citations (Scopus)

Abstract

Recent results on the biology of plasma cells have shown that these cells can survive as long as memory B cells. Possibly, such long-lived plasma cells are also involved in the production of autoantibodies. Here, we discuss the potential involvement of long-lived plasma cells in the pathogenesis of autoimmune disease and the consequences it has for the development of effective therapeutic strategies.

Original language	English
Journal	Immunobiology
Volume	206
Issue number	5
Pages (from-to)	558-562
Number of pages	5
ISSN	0171-2985
DOIs	https://doi.org/10.1078/0171-2985-00204
Publication status	Published - 12.2002

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10.1078/0171-2985-00204

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abstract = "Recent results on the biology of plasma cells have shown that these cells can survive as long as memory B cells. Possibly, such long-lived plasma cells are also involved in the production of autoantibodies. Here, we discuss the potential involvement of long-lived plasma cells in the pathogenesis of autoimmune disease and the consequences it has for the development of effective therapeutic strategies.",

author = "Sergio Arce and Giuliana Cassese and Anja Hauser and Thomas D{\"o}rner and Marcus Odendahl and Rudi Manz and Andreas Radbruch and Falk Hiepe",

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AU - Odendahl, Marcus

AU - Manz, Rudi

AU - Radbruch, Andreas

AU - Hiepe, Falk

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AB - Recent results on the biology of plasma cells have shown that these cells can survive as long as memory B cells. Possibly, such long-lived plasma cells are also involved in the production of autoantibodies. Here, we discuss the potential involvement of long-lived plasma cells in the pathogenesis of autoimmune disease and the consequences it has for the development of effective therapeutic strategies.

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The role of long-lived plasma cells in autoimmunity review

Abstract

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