Abstract
Malignant Mesothelioma (MM) is a very aggressive cancer with low survival rates and often diagnosed at an advanced stage. Several players have been implicated in the development of this cancer, such as asbestos, erionite and the simian virus 40 (SV40). Here, we have reviewed the involvement of erionite, SV40, as well as, the role of several genes (p16INK4a, p14ARF, NF2, LATS2, SAV, CTNNB1 and among others), the pathways (RAS, PI3K, Wnt, BCL and Hippo), and their respective roles in the development of MM.
| Original language | English |
|---|---|
| Journal | Biochimica et Biophysica Acta - Reviews on Cancer |
| Volume | 1845 |
| Issue number | 2 |
| Pages (from-to) | 232-247 |
| Number of pages | 16 |
| ISSN | 0304-419X |
| DOIs | |
| Publication status | Published - 04.2014 |
Funding
The first author of this paper thanks CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) and the Brazilian government through the Science without Borders program for granting a one year full scholarship at the University of Montana, USA; Dr. Mark Pershouse, associate professor of the Department of Biomedical and Pharmaceutical Science at the University of Montana, USA, for his teachings, lessons and mentoring. All the authors of this paper thank Pablo Henrique Oliveira e Silva for extensively revising this manuscript; Izabella Imperatriz Moreira Dalboni de Souza for editing the figures present in this paper; CNPQ and Fundação de Amparo à Pesquisa do estado de Minas Gerais (FAPEMIG , grants APQ 2112-10 and APQ 00793-13 ) for the financial support given to our Laboratory at the Federal University of Ouro Preto (UFOP).
