TY - JOUR
T1 - The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma
AU - De Assis, Leonardo Vinícius Monteiro
AU - Locatelli, Jamille
AU - Isoldi, Mauro César
N1 - Funding Information:
The first author of this paper thanks CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) and the Brazilian government through the Science without Borders program for granting a one year full scholarship at the University of Montana, USA; Dr. Mark Pershouse, associate professor of the Department of Biomedical and Pharmaceutical Science at the University of Montana, USA, for his teachings, lessons and mentoring. All the authors of this paper thank Pablo Henrique Oliveira e Silva for extensively revising this manuscript; Izabella Imperatriz Moreira Dalboni de Souza for editing the figures present in this paper; CNPQ and Fundação de Amparo à Pesquisa do estado de Minas Gerais (FAPEMIG , grants APQ 2112-10 and APQ 00793-13 ) for the financial support given to our Laboratory at the Federal University of Ouro Preto (UFOP).
PY - 2014/4
Y1 - 2014/4
N2 - Malignant Mesothelioma (MM) is a very aggressive cancer with low survival rates and often diagnosed at an advanced stage. Several players have been implicated in the development of this cancer, such as asbestos, erionite and the simian virus 40 (SV40). Here, we have reviewed the involvement of erionite, SV40, as well as, the role of several genes (p16INK4a, p14ARF, NF2, LATS2, SAV, CTNNB1 and among others), the pathways (RAS, PI3K, Wnt, BCL and Hippo), and their respective roles in the development of MM.
AB - Malignant Mesothelioma (MM) is a very aggressive cancer with low survival rates and often diagnosed at an advanced stage. Several players have been implicated in the development of this cancer, such as asbestos, erionite and the simian virus 40 (SV40). Here, we have reviewed the involvement of erionite, SV40, as well as, the role of several genes (p16INK4a, p14ARF, NF2, LATS2, SAV, CTNNB1 and among others), the pathways (RAS, PI3K, Wnt, BCL and Hippo), and their respective roles in the development of MM.
UR - http://www.scopus.com/inward/record.url?scp=84894044731&partnerID=8YFLogxK
U2 - 10.1016/j.bbcan.2014.01.008
DO - 10.1016/j.bbcan.2014.01.008
M3 - Scientific review articles
C2 - 24491449
AN - SCOPUS:84894044731
SN - 0304-419X
VL - 1845
SP - 232
EP - 247
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
IS - 2
ER -
