TY - JOUR
T1 - The results of whole-brain radiotherapy for elderly patients with brain metastases from urinary bladder cancer
AU - Rades, Dirk
AU - Nguyen, Trang
AU - Schild, Steven E.
N1 - Publisher Copyright:
© 2020 International Institute of Anticancer Research. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6
Y1 - 2020/6
N2 - Background/Aim: The number of elderly patients with cancer is growing and requires particular attention. These patients may benefit from personalized treatments. This study aimed to identify prognostic factors of survival for elderly patients (≥65 years) irradiated for brain metastases from urinary bladder cancer. Patients and Methods: In 29 elderly patients treated with whole-brain radiotherapy (WBRT), seven factors were retrospectively analyzed regarding survival, namely dose-fractionation regimen, age, gender, Karnofsky performance score, number of brain metastases, extra-cranial metastases, and interval between cancer diagnosis and WBRT. Results: For the whole series, survival was 38% at 3 months and 21% at 6 months. Karnofsky performance score ≥70% showed a trend for being associated with improved survival when compared to ≤60%; survival rates were 50% vs. 29% at 3 months and 33% vs. 12% at 6 months (p=0.18). Conclusion: Karnofsky performance score may help estimate the survival of elderly patients irradiated for brain metastases from urinary bladder cancer.
AB - Background/Aim: The number of elderly patients with cancer is growing and requires particular attention. These patients may benefit from personalized treatments. This study aimed to identify prognostic factors of survival for elderly patients (≥65 years) irradiated for brain metastases from urinary bladder cancer. Patients and Methods: In 29 elderly patients treated with whole-brain radiotherapy (WBRT), seven factors were retrospectively analyzed regarding survival, namely dose-fractionation regimen, age, gender, Karnofsky performance score, number of brain metastases, extra-cranial metastases, and interval between cancer diagnosis and WBRT. Results: For the whole series, survival was 38% at 3 months and 21% at 6 months. Karnofsky performance score ≥70% showed a trend for being associated with improved survival when compared to ≤60%; survival rates were 50% vs. 29% at 3 months and 33% vs. 12% at 6 months (p=0.18). Conclusion: Karnofsky performance score may help estimate the survival of elderly patients irradiated for brain metastases from urinary bladder cancer.
UR - http://www.scopus.com/inward/record.url?scp=85084276942&partnerID=8YFLogxK
U2 - 10.21873/invivo.11907
DO - 10.21873/invivo.11907
M3 - Journal articles
C2 - 32354924
AN - SCOPUS:85084276942
SN - 0258-851X
VL - 34
SP - 1317
EP - 1320
JO - In Vivo
JF - In Vivo
IS - 3
ER -
