The prognostic impact of the carcinoembryonic antigen in ampullary cancer - A retrospective single center study

Hannah Fuellgraf; Oliver Schilling; Zon Weng Lai; Birte Kulemann; Sylvia Timme; Frank Makowiec; Jasmin H. Shahinian; Jens Hoeppner; Martin Werner; Ulrich T. Hopt; Ulrich F. Wellner; Peter Bronsert

doi:10.7150/jca.16200

The prognostic impact of the carcinoembryonic antigen in ampullary cancer - A retrospective single center study

Hannah Fuellgraf^*, Oliver Schilling, Zon Weng Lai, Birte Kulemann, Sylvia Timme, Frank Makowiec, Jasmin H. Shahinian, Jens Hoeppner, Martin Werner, Ulrich T. Hopt, Ulrich F. Wellner, Peter Bronsert

^*Corresponding author for this work

Department of Surgery

2 Citations (Scopus)

Abstract

Background: Carcinoembryonic antigen cell adhesion molecule (CEA) is a commonly immunohistochemically used antibody in pathological routine diagnostics with an overexpression in different cancers. We aimed to examine the immunohistochemically detectable CEA level in ampullary cancer and to correlate it with clinico-pathological data. Methods: Shot-gun proteomics revealed CEA in undifferentiated ampullary cancer cell lines. Next, tumor tissue of 40 ampullary cancers of a retrospective single center cohort of 40 patients was stained immunohistochemically for CEA; CEA expression was determined and correlated with clinico-pathological data. Results: Thirty-six patient specimens were included in statistical analysis. CEA expression and lymph node ratio (LNR) were the only independent predictors of overall survival in multivariate analysis. Conclusion: To our knowledge, cell line and patient cohorts are the largest and characterized cohorts examined for CEA so far. Hereby, CEA expression in ampullary cancer cells permits an estimation of outcome and suggests an opportunity for individualized CEA-directed therapy. Further trials with larger cohorts are needed to verify our results and to integrate CEA immunohistochemistry into clinical routine.

Original language	English
Journal	Journal of Cancer
Volume	8
Issue number	4
Pages (from-to)	657-664
Number of pages	8
ISSN	0007-0920
DOIs	https://doi.org/10.7150/jca.16200
Publication status	Published - 01.01.2017

Funding

O.S. is supported by grants of the Deutsche Forschungsgemeinschaft (DFG) (SCHI 871/2 and SCHI 871/5, SCHI 871/6, GR 1748/6, and INST 39/900-1) and the SFB850 (Project B8), a starting grant of the European Research Council (Programme "Ideas"-Call identifier: ERC-2011-StG 282111-ProteaSys), and the Excellence Initiative of the German Federal and State Governments (EXC 294, BIOSS). Z.W.L is funded by Marie Curie IIF fellowship (Call Identifier: PIIF-GA-2012-329622 GlycoMarker). The article processing charge was funded by the German Research Foundation (DFG) and the Albert Ludwigs University Freiburg in the funding programme Open Access Publishing.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Research Area: Luebeck Integrated Oncology Network (LION)

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@article{1653e76a23f54c77a71ce89decdcfe14,

title = "The prognostic impact of the carcinoembryonic antigen in ampullary cancer - A retrospective single center study",

abstract = "Background: Carcinoembryonic antigen cell adhesion molecule (CEA) is a commonly immunohistochemically used antibody in pathological routine diagnostics with an overexpression in different cancers. We aimed to examine the immunohistochemically detectable CEA level in ampullary cancer and to correlate it with clinico-pathological data. Methods: Shot-gun proteomics revealed CEA in undifferentiated ampullary cancer cell lines. Next, tumor tissue of 40 ampullary cancers of a retrospective single center cohort of 40 patients was stained immunohistochemically for CEA; CEA expression was determined and correlated with clinico-pathological data. Results: Thirty-six patient specimens were included in statistical analysis. CEA expression and lymph node ratio (LNR) were the only independent predictors of overall survival in multivariate analysis. Conclusion: To our knowledge, cell line and patient cohorts are the largest and characterized cohorts examined for CEA so far. Hereby, CEA expression in ampullary cancer cells permits an estimation of outcome and suggests an opportunity for individualized CEA-directed therapy. Further trials with larger cohorts are needed to verify our results and to integrate CEA immunohistochemistry into clinical routine.",

author = "Hannah Fuellgraf and Oliver Schilling and Lai, \{Zon Weng\} and Birte Kulemann and Sylvia Timme and Frank Makowiec and Shahinian, \{Jasmin H.\} and Jens Hoeppner and Martin Werner and Hopt, \{Ulrich T.\} and Wellner, \{Ulrich F.\} and Peter Bronsert",

year = "2017",

month = jan,

day = "1",

doi = "10.7150/jca.16200",

language = "English",

volume = "8",

pages = "657--664",

journal = "Journal of Cancer",

issn = "0007-0920",

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number = "4",

}

TY - JOUR

T1 - The prognostic impact of the carcinoembryonic antigen in ampullary cancer - A retrospective single center study

AU - Fuellgraf, Hannah

AU - Schilling, Oliver

AU - Lai, Zon Weng

AU - Kulemann, Birte

AU - Timme, Sylvia

AU - Makowiec, Frank

AU - Shahinian, Jasmin H.

AU - Hoeppner, Jens

AU - Werner, Martin

AU - Hopt, Ulrich T.

AU - Wellner, Ulrich F.

AU - Bronsert, Peter

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Carcinoembryonic antigen cell adhesion molecule (CEA) is a commonly immunohistochemically used antibody in pathological routine diagnostics with an overexpression in different cancers. We aimed to examine the immunohistochemically detectable CEA level in ampullary cancer and to correlate it with clinico-pathological data. Methods: Shot-gun proteomics revealed CEA in undifferentiated ampullary cancer cell lines. Next, tumor tissue of 40 ampullary cancers of a retrospective single center cohort of 40 patients was stained immunohistochemically for CEA; CEA expression was determined and correlated with clinico-pathological data. Results: Thirty-six patient specimens were included in statistical analysis. CEA expression and lymph node ratio (LNR) were the only independent predictors of overall survival in multivariate analysis. Conclusion: To our knowledge, cell line and patient cohorts are the largest and characterized cohorts examined for CEA so far. Hereby, CEA expression in ampullary cancer cells permits an estimation of outcome and suggests an opportunity for individualized CEA-directed therapy. Further trials with larger cohorts are needed to verify our results and to integrate CEA immunohistochemistry into clinical routine.

AB - Background: Carcinoembryonic antigen cell adhesion molecule (CEA) is a commonly immunohistochemically used antibody in pathological routine diagnostics with an overexpression in different cancers. We aimed to examine the immunohistochemically detectable CEA level in ampullary cancer and to correlate it with clinico-pathological data. Methods: Shot-gun proteomics revealed CEA in undifferentiated ampullary cancer cell lines. Next, tumor tissue of 40 ampullary cancers of a retrospective single center cohort of 40 patients was stained immunohistochemically for CEA; CEA expression was determined and correlated with clinico-pathological data. Results: Thirty-six patient specimens were included in statistical analysis. CEA expression and lymph node ratio (LNR) were the only independent predictors of overall survival in multivariate analysis. Conclusion: To our knowledge, cell line and patient cohorts are the largest and characterized cohorts examined for CEA so far. Hereby, CEA expression in ampullary cancer cells permits an estimation of outcome and suggests an opportunity for individualized CEA-directed therapy. Further trials with larger cohorts are needed to verify our results and to integrate CEA immunohistochemistry into clinical routine.

UR - https://www.scopus.com/pages/publications/85013973398

U2 - 10.7150/jca.16200

DO - 10.7150/jca.16200

M3 - Journal articles

AN - SCOPUS:85013973398

SN - 0007-0920

VL - 8

SP - 657

EP - 664

JO - Journal of Cancer

JF - Journal of Cancer

IS - 4

ER -

The prognostic impact of the carcinoembryonic antigen in ampullary cancer - A retrospective single center study

Abstract

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