The prognostic impact of age in patients with triple-negative breast cancer

Cornelia Liedtke*, K. R. Hess, T. Karn, A. Rody, L. Kiesel, G. N. Hortobagyi, L. Pusztai, A. M. Gonzalez-Angulo

*Corresponding author for this work
24 Citations (Scopus)

Abstract

The purpose of this study was to assess the prognostic impact of age in patients with triple-negative breast cancer (TNBC). 1,732 patients with primary TNBC were analyzed. Five age cohorts (≤30, 31-40, 41-50, 51-60, and >60 years) at diagnosis were correlated with clinical/pathological parameters. Univariate and multivariate analyses were used to examine the effect of age on disease-free (DFS), distant disease-free (DDFS), and overall survival (OS). In patients with TNBC, increasing age at diagnosis was inversely correlated with tumor grade (P < 0.0001); likelihood of being non-Caucasian (P = 0.0001); likelihood of getting chemotherapy (P < 0.0001); and positively correlated with DFS (P = 0.0003); DDFS (P < 0.0001); and OS (P < 0.0001). The median DFS for patients 31-40 and older than 60 years was 4 years [95 % confidence interval (95 % CI) 2-5] and 8 years (95 % CI 5-14, respectively, P = 0.0003). The DDFS and OS were also statistically significantly shorter for younger patients. In multivariate analysis, tumor size, nodal stage, tumor grade, and age remained significant independent prognostic variables. Clinical characteristics of TNBC differ by age group, patients ≤40 years have poorer survival despite more aggressive systemic therapy.

Original languageEnglish
JournalBreast Cancer Research and Treatment
Volume138
Issue number2
Pages (from-to)591-599
Number of pages9
ISSN0167-6806
DOIs
Publication statusPublished - 01.04.2013

Fingerprint

Dive into the research topics of 'The prognostic impact of age in patients with triple-negative breast cancer'. Together they form a unique fingerprint.

Cite this