The potential role of G2- but not of G0-radiosensitivity for predisposition of prostate cancer

Kerstin Borgmann, Annette Raabe, Sebastian Reuther, Silke Szymczak, Thorsten Schlomm, Hendrik Isbarn, Maria Gomolka, Andreas Busjahn, Michael Bonin, Andreas Ziegler, Ekkehard Dikomey*

*Corresponding author for this work
14 Citations (Scopus)


Purpose: Comparing the chromosomal radiosensitivity of prostate cancer patients with that of healthy donors. Materials and methods: The study was performed on 81 prostate cancer patients characterised by a clinical stage of predominantly pT2c or pT3a and a median age of 67 years. As healthy donors 60 male monozygotic twin pairs were recruited with a median age of 28 years. Chromosomal radiosensitivity was measured using both G0- and G2-assay. Results: No difference between healthy donors and prostate cancer patients was detected concerning G0-radiosensitivity, since medians were similar (Hodges-Lehmann estimate: -0.05, 95% CI: -0.18-0.08, p = 0.4167). However, a pronounced difference was determined for G2-radiosensitivity with prostate cancer patients showing a significantly higher sensitivity compared to healthy donors (Hodges-Lehmann estimate: -0.41, 95% CI: -0.53 to -0.30, p = 1.75 -9). Using the 90% quantile of G2-radiosensitivity in healthy donors as a threshold for discrimination the fraction of prostate cancer patients with elevated radiosensitivity increased to 49%. Conclusion: G2-, but not G0-radiosensitivity is a promising marker for predisposition of prostate cancer.

Original languageEnglish
JournalRadiotherapy and Oncology
Issue number1
Pages (from-to)19-24
Number of pages6
Publication statusPublished - 07.2010


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