Abstract
In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.
| Original language | English |
|---|---|
| Journal | Cell |
| Volume | 142 |
| Issue number | 3 |
| Pages (from-to) | 368-374 |
| Number of pages | 7 |
| ISSN | 0092-8674 |
| DOIs | |
| Publication status | Published - 01.08.2010 |
Funding
We thank Chenguang Gong and Hanae Sato for helpful comments and acknowledge NIH R01 grants GM074593 and GM59614 (L.E.M.), the National Science Council of Taiwan (W.-Y.T.), and start-up funds from the University of Lübeck (O.I.) for support.
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
