The pioneer round of translation: Features and functions

Lynne E. Maquat; Woan Yuh Tarn; Olaf Isken

doi:10.1016/j.cell.2010.07.022

The pioneer round of translation: Features and functions

Lynne E. Maquat^*, Woan Yuh Tarn, Olaf Isken

^*Corresponding author for this work

Institute of Virology and Cell Biology

99 Citations (Scopus)

Abstract

In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.

Original language	English
Journal	Cell
Volume	142
Issue number	3
Pages (from-to)	368-374
Number of pages	7
ISSN	0092-8674
DOIs	https://doi.org/10.1016/j.cell.2010.07.022
Publication status	Published - 01.08.2010

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cell.2010.07.022

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title = "The pioneer round of translation: Features and functions",

abstract = "In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.",

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AU - Isken, Olaf

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N2 - In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.

AB - In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.

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U2 - 10.1016/j.cell.2010.07.022

DO - 10.1016/j.cell.2010.07.022

M3 - Scientific review articles

C2 - 20691898

AN - SCOPUS:77955326776

SN - 0092-8674

VL - 142

SP - 368

EP - 374

JO - Cell

JF - Cell

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The pioneer round of translation: Features and functions

Abstract

Research Areas and Centers

UN SDGs

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