TY - JOUR
T1 - The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia
AU - Gröschel, Matthias I.
AU - Meehan, Conor J.
AU - Barilar, Ivan
AU - Diricks, Margo
AU - Gonzaga, Aitor
AU - Steglich, Matthias
AU - Conchillo-Solé, Oscar
AU - Scherer, Isabell Christin
AU - Mamat, Uwe
AU - Luz, Christian F.
AU - De Bruyne, Katrien
AU - Utpatel, Christian
AU - Yero, Daniel
AU - Gibert, Isidre
AU - Daura, Xavier
AU - Kampmeier, Stefanie
AU - Rahman, Nurdyana Abdul
AU - Kresken, Michael
AU - van der Werf, Tjip S.
AU - Alio, Ifey
AU - Streit, Wolfgang R.
AU - Zhou, Kai
AU - Schwartz, Thomas
AU - Rossen, John W.A.
AU - Farhat, Maha R.
AU - Schaible, Ulrich E.
AU - Nübel, Ulrich
AU - Rupp, Jan
AU - Steinmann, Joerg
AU - Niemann, Stefan
AU - Kohl, Thomas A.
N1 - Funding Information:
We thank V. Mohr, F. Boysen and T. Ubben for technical assistance during next-generation sequencings. Parts of the work have been funded by grants from German Center for Infection Research, Federal Ministry of Education and Research, Germany, from Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy–EXC 22167-390884018, the Cluster Precision Medicine in Chronic Inflammation, and grants from the Leibniz Science Campus Evo-LUNG; I.A. and W.R.S. received funds from the University of Hamburg; C.F.L. and J.W.A.R. were funded through the European Commission Horizon 2020 Framework Marie Skłodowska-Curie Actions (Grant agreement number: 713660 - PRONKJE-WAIL - H2020-MSCA-COFUND-2015); C.J.M. was funded by the Department of Economy, Science and Innovation of the Flemish Government and the Belgian Science Policy (Belspo); K.Z. was funded by the National Natural Science Foundation of China (grant number 81702045), and 13th Five-Year National Major Science and Technology Projects of China (grant number 2018ZX10712001); O.C.S., D.Y., I.G. and X.D. were funded by the Spanish Ministry for Science, Innovation and Universities (grant reference BIO2015-66674-R); N.A.R. was funded by the SingHealth DUKE-NUS Pathology Academic Clinical Programme Clinical Innovation Support Grant (09/FY2017/P1/06-A20); U.N. was funded by the EU Horizon 2020 programme, grant agreement number 643476.
Publisher Copyright:
© 2020, The Author(s).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals.
AB - Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals.
UR - http://www.scopus.com/inward/record.url?scp=85083972595&partnerID=8YFLogxK
U2 - 10.1038/s41467-020-15123-0
DO - 10.1038/s41467-020-15123-0
M3 - Journal articles
C2 - 32341346
AN - SCOPUS:85083972595
SN - 1751-8628
VL - 11
SP - 2044
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 2044
ER -
