Abstract
Background: The cytokine transforming growth factor- (TGF-β) is a pivotal contributor to tissue fibrosis and a key cytokine in the pathogenesis of cellular transdifferentiation, epithelial-mesenchymal transition (EMT), and cell adhesion. This study evaluates the effect of decorin, a naturally occurring TGF-β inhibitor, in an experimental rabbit model for proliferative vitreoretinopathy (PVR). Methods: Traumatic PVR was induced in 50 rabbits divided into ten groups (n=5). One group (GI) reveals a control with no treatment after trauma. Groups (GII-GIV) consisted of subgroups receiving phacovitrectomy at three different time points; (a) at the time of trauma, (b) 1 week following trauma, and (c) 2 weeks following trauma. GIII and GIV received 100 μg or 200 μg decorin, respectively. PVR severity was scored from 0 to 4. The amount of fibrosis was quantified using JMicroVision
| Original language | English |
|---|---|
| Journal | Graefe's Archive for Clinical and Experimental Ophthalmology |
| Volume | 249 |
| Issue number | 11 |
| Pages (from-to) | 1649-1660 |
| Number of pages | 12 |
| ISSN | 0721-832X |
| DOIs | |
| Publication status | Published - 11.2011 |
Funding
Acknowledgements This study was supported in part by Herbert Funke Foundation, Germany and by the ministry of high education of the Egyptian government. We thank Mrs. Christine Örün for her technical assistance.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Research Areas and Centers
- Research Area: Luebeck Integrated Oncology Network (LION)
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