The New Haseman-Elston Method and the Weighted Pairwise Correlation Statistic Are Variations on the Same Theme

Andreas Ziegler*

*Corresponding author for this work
7 Citations (Scopus)

Abstract

Model free linkage analysis of quantitative traits has become increasingly popular in recent years. Its basic idea is to use the principle of similarity: Sib pairs that are genetically (dis)similar at a linked marker should be phenotypically (dis)similar and vice versa. The classical Haseman-Elston method, the new Haseman-Elston (nHE) method and the weighted pairwise correlation (WPC) method follow this principle. Similarities and differences between these approaches are discussed. It is proven that the nHE and the WPC statistic are identical under specific regularity conditions. It is furthermore demonstrated that the nHE and the WPC method are expected to yield similar results for a broad range of models. Finally, it is shown that it is impossible to a priori determine whether the nHE method or the WPC method has greater power to detect linkage under general genetic models.

Original languageEnglish
JournalBiometrical Journal
Volume43
Issue number6
Pages (from-to)697-702
Number of pages6
ISSN0323-3847
DOIs
Publication statusPublished - 2001

Fingerprint

Dive into the research topics of 'The New Haseman-Elston Method and the Weighted Pairwise Correlation Statistic Are Variations on the Same Theme'. Together they form a unique fingerprint.

Cite this