The molecular basis of male sexual differentiation

Olaf Hiort*, Paul Martin Holterhus

*Corresponding author for this work
62 Citations (Scopus)


Male sexual differentiation is the result of complex mechanisms involving developmental genetics and endocrinology. Formation of the bipotential gonads and subsequently the testes is dependent on a series of sex chromosome-linked and autosomal genes. The testes secrete both peptide and steroid hormones essential for the formation of internal and external genitalia. Hormone action is mediated via specific receptors, functioning as transcription regulators. Disruption of these genetic events leads to sexual dimorphism involving external and internal genitalia, and may also interfere with the development of other organs.

Original languageEnglish
JournalEuropean Journal of Endocrinology
Issue number2
Pages (from-to)101-110
Number of pages10
Publication statusPublished - 02.2000

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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