The memory function of sleep

Susanne Diekelmann; Jan Born

doi:10.1038/nrn2762

The memory function of sleep

Susanne Diekelmann, Jan Born^*

^*Corresponding author for this work

2908 Citations (Scopus)

Abstract

Sleep has been identified as a state that optimizes the consolidation of newly acquired information in memory, depending on the specific conditions of learning and the timing of sleep. Consolidation during sleep promotes both quantitative and qualitative changes of memory representations. Through specific patterns of neuromodulatory activity and electric field potential oscillations, slow-wave sleep (SWS) and rapid eye movement (REM) sleep support system consolidation and synaptic consolidation, respectively. During SWS, slow oscillations, spindles and ripples at minimum cholinergic activity coordinate the re-activation and redistribution of hippocampus-dependent memories to neocortical sites, whereas during REM sleep, local increases in plasticity-related immediate-early gene activity at high cholinergic and theta activity might favour the subsequent synaptic consolidation of memories in the cortex.

Original language	English
Journal	Nature Reviews Neuroscience
Volume	11
Issue number	2
Pages (from-to)	114-126
Number of pages	13
ISSN	1471-003X
DOIs	https://doi.org/10.1038/nrn2762
Publication status	Published - 01.02.2010

Funding

We apologize to those whose work was not cited because of space constraints. We thank Drs. B. Rasch, L. Marshall, I. Wilhelm, M. Hallschmid, E. Robertson and S. Ribeiro for helpful discussions and comments on earlier drafts. This work was supported by a grant from the Deutsche Forschungsgemeinschaft (SFB 654 ‘Plasticity and Sleep’).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrn2762

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The memory function of sleep

Abstract

Funding

UN SDGs

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Graduate School GSC 235: Graduate School for Computing in Medicine and Life Sciences

Cite this

The memory function of sleep

Abstract

Funding

UN SDGs

Access to Document

Other files and links

Fingerprint

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Graduate School GSC 235: Graduate School for Computing in Medicine and Life Sciences

Cite this