The interface between thyroid and diabetes mellitus

Leonidas H. Duntas, Jacques Orgiazzi, Georg Brabant*

*Corresponding author for this work
75 Citations (Scopus)


Thyroid disease and type 1 but also type 2 diabetes mellitus (DM) are strongly associated, and this has important clinical implications for insulin sensitivity and treatment requirements. The pathophysiological basis of this association has only recently been better elucidated. It rests on a complex interaction of common signalling pathways and, in the case of type 1 diabetes and autoimmune thyroid disease, on a linked genetic susceptibility. The pathophysiological mechanisms underlying this linked regulation are increasingly being unravelled. They are exemplified in the regulation of 5′ adenosine monophosphate-activated protein kinase (AMPK), a central target not only for the modulation of insulin sensitivity but also for the feedback of thyroid hormones on appetite and energy expenditure. The present review will discuss these concepts and their consequences for the clinical care of patients with DM and thyroid disorders. Moreover, it makes reference to the added effect of metformin in suppressing TSH.

Original languageEnglish
JournalClinical Endocrinology
Issue number1
Pages (from-to)1-9
Number of pages9
Publication statusPublished - 01.01.2011

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


Dive into the research topics of 'The interface between thyroid and diabetes mellitus'. Together they form a unique fingerprint.

Cite this