TY - JOUR
T1 - The Influence of Thyroid Hormones on Brain Structure and Function in Humans
AU - Göbel, Anna
AU - Göttlich, Martin
AU - Reinwald, Jonathan
AU - Rogge, Berenike
AU - Uter, Jan Christoph
AU - Heldmann, Marcus
AU - Heldmann, Marcus
AU - Sartorius, Alexander
AU - Brabant, Georg
AU - Münte, Thomas F.
N1 - Funding Information:
This study was supported by the DFG MU1311/16–2 awarded to
Publisher Copyright:
© 2020 J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart New York.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - The pleiotropic function of thyroid hormones (TH) is mediated by an organ specific expression of thyroid hormone transporters, deiodinases and TH receptors. In a series of studies we used the model of an experimentally induced hyper- or hypothyroidism in human volunteers to delineate TH action on the brain. A battery of neuropsychological testing paradigms was employed and complemented by structural and functional multimodal neuroimaging. Experimentally induced mild thyrotoxicosis for 6 weeks was associated with changes in brain structure (determined with voxel-based morphometry), resting state functional connectivity, and task-related functional activation in a working memory paradigm. Partial withdrawal of TH replacement in patients without thyroid (subclinical hypothyroidism) likewise lead to changes on multiple functional and structural brain measures. Importantly, the series of studies reviewed here identified the cerebellum as one crucial site of action.
AB - The pleiotropic function of thyroid hormones (TH) is mediated by an organ specific expression of thyroid hormone transporters, deiodinases and TH receptors. In a series of studies we used the model of an experimentally induced hyper- or hypothyroidism in human volunteers to delineate TH action on the brain. A battery of neuropsychological testing paradigms was employed and complemented by structural and functional multimodal neuroimaging. Experimentally induced mild thyrotoxicosis for 6 weeks was associated with changes in brain structure (determined with voxel-based morphometry), resting state functional connectivity, and task-related functional activation in a working memory paradigm. Partial withdrawal of TH replacement in patients without thyroid (subclinical hypothyroidism) likewise lead to changes on multiple functional and structural brain measures. Importantly, the series of studies reviewed here identified the cerebellum as one crucial site of action.
UR - http://www.scopus.com/inward/record.url?scp=85086682900&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/2b6e8311-4503-3f23-ab9b-2932901b5f22/
U2 - 10.1055/a-1101-9090
DO - 10.1055/a-1101-9090
M3 - Scientific review articles
C2 - 32040963
AN - SCOPUS:85086682900
SN - 0947-7349
VL - 128
SP - 432
EP - 436
JO - Experimental and Clinical Endocrinology and Diabetes
JF - Experimental and Clinical Endocrinology and Diabetes
IS - 6-7
ER -
