The indoleamine 2,3-dioxygenase (IDO) pathway controls allergy

D. Von Bubnoff*, T. Bieber

*Corresponding author for this work
39 Citations (Scopus)


A series of recent studies have demonstrated that the immunoregulatory pathway of tryptophan catabolism, initiated by the enzyme indoleamine 2,3-dioxygenase (IDO), is a critical participant in allergic inflammation. Originally known for its regulatory function during pregnancy and during chronic inflammation in tumorigenesis and infection, the activity of IDO seems to positively modify the inflammatory state of atopy or allergy. The tryptophan degradation pathway is important for tolerance induction during systemic allergen immunotherapy. Here, we focus on recent findings that establish the IDO pathway as central to allergic inflammation.

Original languageEnglish
JournalAllergy: European Journal of Allergy and Clinical Immunology
Issue number6
Pages (from-to)718-725
Number of pages8
Publication statusPublished - 06.2012


Dive into the research topics of 'The indoleamine 2,3-dioxygenase (IDO) pathway controls allergy'. Together they form a unique fingerprint.

Cite this