TY - JOUR
T1 - The indoleamine 2,3-dioxygenase (IDO) pathway controls allergy
AU - Von Bubnoff, D.
AU - Bieber, T.
PY - 2012/6
Y1 - 2012/6
N2 - A series of recent studies have demonstrated that the immunoregulatory pathway of tryptophan catabolism, initiated by the enzyme indoleamine 2,3-dioxygenase (IDO), is a critical participant in allergic inflammation. Originally known for its regulatory function during pregnancy and during chronic inflammation in tumorigenesis and infection, the activity of IDO seems to positively modify the inflammatory state of atopy or allergy. The tryptophan degradation pathway is important for tolerance induction during systemic allergen immunotherapy. Here, we focus on recent findings that establish the IDO pathway as central to allergic inflammation.
AB - A series of recent studies have demonstrated that the immunoregulatory pathway of tryptophan catabolism, initiated by the enzyme indoleamine 2,3-dioxygenase (IDO), is a critical participant in allergic inflammation. Originally known for its regulatory function during pregnancy and during chronic inflammation in tumorigenesis and infection, the activity of IDO seems to positively modify the inflammatory state of atopy or allergy. The tryptophan degradation pathway is important for tolerance induction during systemic allergen immunotherapy. Here, we focus on recent findings that establish the IDO pathway as central to allergic inflammation.
UR - http://www.scopus.com/inward/record.url?scp=84861093525&partnerID=8YFLogxK
U2 - 10.1111/j.1398-9995.2012.02830.x
DO - 10.1111/j.1398-9995.2012.02830.x
M3 - Scientific review articles
C2 - 22519427
AN - SCOPUS:84861093525
SN - 0105-4538
VL - 67
SP - 718
EP - 725
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
IS - 6
ER -
