TY - JOUR
T1 - The impact of simultaneous intoxication with agrochemicals on the antioxidant defense system in rat
AU - Astiz, Mariana
AU - de Alaniz, María J.T.
AU - Marra, Carlos Alberto
N1 - Funding Information:
This study was supported by a Grant from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). We would like to thank Miss Norma Cristalli for technical assistance.
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/6
Y1 - 2009/6
N2 - It is known that the presence of pesticides may alter the reproductive performance of animals. We studied the effect of chronic pesticide exposure in rats injected i.p. for 5 weeks with doses between 1/50 and 1/250 LD50 of dimethoate, glyphosate and zineb, either alone or in combination. All tested agrochemicals increased the oxidative stress status in the plasma, liver, and testes, and also modified hormonal parameters involved in reproductive function. The increase in oxidative stress and damage biomarker levels, as well as the alteration of the antioxidant defence system decreased testosterone, FSH and LH levels in the plasma of pesticide-treated rats. These effects were more pronounced when pesticides were administered in combination, and should be considered indicative of involuntary exposure to residual agrochemicals.
AB - It is known that the presence of pesticides may alter the reproductive performance of animals. We studied the effect of chronic pesticide exposure in rats injected i.p. for 5 weeks with doses between 1/50 and 1/250 LD50 of dimethoate, glyphosate and zineb, either alone or in combination. All tested agrochemicals increased the oxidative stress status in the plasma, liver, and testes, and also modified hormonal parameters involved in reproductive function. The increase in oxidative stress and damage biomarker levels, as well as the alteration of the antioxidant defence system decreased testosterone, FSH and LH levels in the plasma of pesticide-treated rats. These effects were more pronounced when pesticides were administered in combination, and should be considered indicative of involuntary exposure to residual agrochemicals.
UR - http://www.scopus.com/inward/record.url?scp=67349155329&partnerID=8YFLogxK
U2 - 10.1016/j.pestbp.2009.03.005
DO - 10.1016/j.pestbp.2009.03.005
M3 - Journal articles
AN - SCOPUS:67349155329
SN - 0048-3575
VL - 94
SP - 93
EP - 99
JO - Pesticide Biochemistry and Physiology
JF - Pesticide Biochemistry and Physiology
IS - 2-3
ER -
