The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection

M. Longoni; C. Grond-Ginsbach; A. J. Grau; J. Genius; S. Debette; M. Schwaninger; C. Ferrarese; C. Lichy

doi:10.1212/01.wnl.0000208411.01172.0b

The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection

M. Longoni^*, C. Grond-Ginsbach, A. J. Grau, J. Genius, S. Debette, M. Schwaninger, C. Ferrarese, C. Lichy

^*Corresponding author for this work

Institute of Experimental and Clinical Pharmacology and Toxicology

32 Citations (Scopus)

Abstract

In a primary study on proinflammatory genetic profiles in stroke, the authors found the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1) highly represented in the subgroup with spontaneous cervical artery dissection (sCAD). They further investigated the same genetic variant in a second group of 65 patients with sCAD. An association between sCAD and EE genotype was confirmed (odds ratio 3.16; p < 0.01), indicating that a proinflammatory predisposition is a risk factor for sCAD.

Original language	English
Journal	Neurology
Volume	66
Issue number	8
Pages (from-to)	1273-1275
Number of pages	3
ISSN	0028-3878
DOIs	https://doi.org/10.1212/01.wnl.0000208411.01172.0b
Publication status	Published - 01.04.2006

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1212/01.wnl.0000208411.01172.0b

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title = "The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection",

abstract = "In a primary study on proinflammatory genetic profiles in stroke, the authors found the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1) highly represented in the subgroup with spontaneous cervical artery dissection (sCAD). They further investigated the same genetic variant in a second group of 65 patients with sCAD. An association between sCAD and EE genotype was confirmed (odds ratio 3.16; p < 0.01), indicating that a proinflammatory predisposition is a risk factor for sCAD.",

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AU - Longoni, M.

AU - Grond-Ginsbach, C.

AU - Grau, A. J.

AU - Genius, J.

AU - Debette, S.

AU - Schwaninger, M.

AU - Ferrarese, C.

AU - Lichy, C.

PY - 2006/4/1

Y1 - 2006/4/1

N2 - In a primary study on proinflammatory genetic profiles in stroke, the authors found the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1) highly represented in the subgroup with spontaneous cervical artery dissection (sCAD). They further investigated the same genetic variant in a second group of 65 patients with sCAD. An association between sCAD and EE genotype was confirmed (odds ratio 3.16; p < 0.01), indicating that a proinflammatory predisposition is a risk factor for sCAD.

AB - In a primary study on proinflammatory genetic profiles in stroke, the authors found the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1) highly represented in the subgroup with spontaneous cervical artery dissection (sCAD). They further investigated the same genetic variant in a second group of 65 patients with sCAD. An association between sCAD and EE genotype was confirmed (odds ratio 3.16; p < 0.01), indicating that a proinflammatory predisposition is a risk factor for sCAD.

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DO - 10.1212/01.wnl.0000208411.01172.0b

M3 - Journal articles

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SN - 0028-3878

VL - 66

SP - 1273

EP - 1275

JO - Neurology

JF - Neurology

IS - 8

ER -

The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection

Abstract

Research Areas and Centers

UN SDGs

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