Abstract
Since its first description in 2009,1 the Aldara™ (MEDA Pharma GmbH, Bad Homburg, Germany)‐induced psoriasiform dermatitis (AIPD) model has become a most commonly used mouse model of plaque psoriasis. It is mostly conducted in the C57Bl/6 mouse strain. Two substrains of this mouse strain, C57Bl/6J and C57Bl/6N, are in parallel widely used for research purposes. The two substrains are phenotypically identical but genetically differ by 34 SNPs, two indels and 15 gene variants that overlap a gene.2-4 Notably, gene knockout and transgenic mice on the C57Bl/6 background are often held on an intermediate genotype between the two substrains due to incomplete backcrossing after genetic manipulation. This issue has become even more common in recent years with the International Knockout Mouse Consortium's (IKMC) decision to preferentially generate genetic knockouts in C57Bl/6N embryonic stem cells,4 while, in contrast, most investigators still preferably use C57Bl/6J mice.
| Original language | English |
|---|---|
| Journal | Experimental Dermatology |
| Volume | 26 |
| Issue number | 4 |
| Pages (from-to) | 349-351 |
| Number of pages | 3 |
| ISSN | 0906-6705 |
| DOIs | |
| Publication status | Published - 01.04.2017 |
Funding
This work was supported by the Deutsche Forschungsgemeinschaft (KFO 303; Sa1960/5-1). C.D.S. designed the research study, analysed and wrote the manuscript; S.B. performed the research and analysed results; A.H., T.S. and S.M. performed the research; D.Z., S.I. and R.J.L analysed data and wrote the manuscript. All author approved the final version of the article and consented to its publication.
