The functional role of cerebral ATP levels in body weight regulation

Kamila Jauch-Chara*, Kerstin M. Oltmanns

*Corresponding author for this work


Adenosine triphosphate (ATP) is ubiquitously used for intracellular chemical energy transfer processes in the entire organism. Within the brain, however, ATP takes on a special functional role, which exceeds by far its peripheral mission as local cellular energy supplier. Neuronal ATP levels exert a dominating influence on downstream metabolic systems regulated by corresponding functional brain areas and therefore control decisive factors of the organismic energy homeostasis such as energy expenditure and food intake behavior. The first part of this chapter outlines i) how physiological brain energy supply for ATP synthesis occurs, ii) the function of ATP-sensitive potassium channels in this context, and iii) the homeostatic regulation of ATP levels upon neuronal excitation and inhibition. In the second part, we aim to iv) give an overview on the current knowledge how cerebral ATP levels and systemic metabolic processes interact and v) explain the specific impact of this interaction on body weight regulation in a physiologic and a pathologic state.

Original languageEnglish
Title of host publicationAdenosine Triphosphate: Chemical Properties, Biosynthesis and Functions in Cells
Number of pages18
PublisherNova Science Publishers, Inc.
Publication date2013
ISBN (Print)9781624178900
Publication statusPublished - 2013

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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