The functional polymorphism 844 A>G in Fc αRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility

Jasper C.A. Broen; Marieke J.H. Coenen; Blanca Rueda; Torsten Witte; Leonid Padyukov; Lars Klareskog; Roger Hesselstrand; Dirk M. Wuttge; Carmen Simeon; Norberto Ortego-Centeno; Miguel A. González-Gay; Anna Pros; Nicholas Hunzelman; Gabriela Riemekasten; Alexander Kreuter; Madelon Vonk; Rafaella Scorza; Lorenzo Beretta; Paulo Airò; Piet L.C.M. Van Riel; Robert Kimberly; Javier Martin; Jeffrey Edberg; Timothy R.D.J. Radstake

doi:10.3899/jrheum.100427

The functional polymorphism 844 A>G in Fc _αRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility

Jasper C.A. Broen, Marieke J.H. Coenen, Blanca Rueda, Torsten Witte, Leonid Padyukov, Lars Klareskog, Roger Hesselstrand, Dirk M. Wuttge, Carmen Simeon, Norberto Ortego-Centeno, Miguel A. González-Gay, Anna Pros, Nicholas Hunzelman, Gabriela Riemekasten, Alexander Kreuter, Madelon Vonk, Rafaella Scorza, Lorenzo Beretta, Paulo Airò, Piet L.C.M. Van RielRobert Kimberly, Javier Martin, Jeffrey Edberg, Timothy R.D.J. Radstake

Clinic of Rheumatology

4 Citations (Scopus)

Abstract

Objective. To investigate the role of the Fc _αRI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. Methods. The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc _αRI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. Results. We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. Conclusion. Our data show that the Fc _αRI 844 A>G polymorphism is not associated with SSc or RA susceptibility. The Journal of Rheumatology

Original language	English
Journal	Journal of Rheumatology
Volume	38
Issue number	3
Pages (from-to)	446-449
Number of pages	4
ISSN	0315-162X
DOIs	https://doi.org/10.3899/jrheum.100427
Publication status	Published - 03.2011

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3899/jrheum.100427

Cite this

Broen, J. C. A., Coenen, M. J. H., Rueda, B., Witte, T., Padyukov, L., Klareskog, L., Hesselstrand, R., Wuttge, D. M., Simeon, C., Ortego-Centeno, N., González-Gay, M. A., Pros, A., Hunzelman, N., Riemekasten, G., Kreuter, A., Vonk, M., Scorza, R., Beretta, L., Airò, P., ... Radstake, T. R. D. J. (2011). The functional polymorphism 844 A>G in Fc _αRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility. Journal of Rheumatology, 38(3), 446-449. https://doi.org/10.3899/jrheum.100427

@article{e89d10062ce54655a6f76171653794a6,

title = "The functional polymorphism 844 A>G in Fc αRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility",

abstract = "Objective. To investigate the role of the Fc αRI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. Methods. The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc αRI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. Results. We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. Conclusion. Our data show that the Fc αRI 844 A>G polymorphism is not associated with SSc or RA susceptibility. The Journal of Rheumatology",

author = "Broen, {Jasper C.A.} and Coenen, {Marieke J.H.} and Blanca Rueda and Torsten Witte and Leonid Padyukov and Lars Klareskog and Roger Hesselstrand and Wuttge, {Dirk M.} and Carmen Simeon and Norberto Ortego-Centeno and Gonz{\'a}lez-Gay, {Miguel A.} and Anna Pros and Nicholas Hunzelman and Gabriela Riemekasten and Alexander Kreuter and Madelon Vonk and Rafaella Scorza and Lorenzo Beretta and Paulo Air{\`o} and {Van Riel}, {Piet L.C.M.} and Robert Kimberly and Javier Martin and Jeffrey Edberg and Radstake, {Timothy R.D.J.}",

year = "2011",

month = mar,

doi = "10.3899/jrheum.100427",

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Broen, JCA, Coenen, MJH, Rueda, B, Witte, T, Padyukov, L, Klareskog, L, Hesselstrand, R, Wuttge, DM, Simeon, C, Ortego-Centeno, N, González-Gay, MA, Pros, A, Hunzelman, N, Riemekasten, G, Kreuter, A, Vonk, M, Scorza, R, Beretta, L, Airò, P, Van Riel, PLCM, Kimberly, R, Martin, J, Edberg, J & Radstake, TRDJ 2011, 'The functional polymorphism 844 A>G in Fc _αRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility', Journal of Rheumatology, vol. 38, no. 3, pp. 446-449. https://doi.org/10.3899/jrheum.100427

TY - JOUR

T1 - The functional polymorphism 844 A>G in Fc αRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility

AU - Broen, Jasper C.A.

AU - Coenen, Marieke J.H.

AU - Rueda, Blanca

AU - Witte, Torsten

AU - Padyukov, Leonid

AU - Klareskog, Lars

AU - Hesselstrand, Roger

AU - Wuttge, Dirk M.

AU - Simeon, Carmen

AU - Ortego-Centeno, Norberto

AU - González-Gay, Miguel A.

AU - Pros, Anna

AU - Hunzelman, Nicholas

AU - Riemekasten, Gabriela

AU - Kreuter, Alexander

AU - Vonk, Madelon

AU - Scorza, Rafaella

AU - Beretta, Lorenzo

AU - Airò, Paulo

AU - Van Riel, Piet L.C.M.

AU - Kimberly, Robert

AU - Martin, Javier

AU - Edberg, Jeffrey

AU - Radstake, Timothy R.D.J.

PY - 2011/3

Y1 - 2011/3

N2 - Objective. To investigate the role of the Fc αRI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. Methods. The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc αRI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. Results. We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. Conclusion. Our data show that the Fc αRI 844 A>G polymorphism is not associated with SSc or RA susceptibility. The Journal of Rheumatology

AB - Objective. To investigate the role of the Fc αRI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. Methods. The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc αRI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. Results. We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. Conclusion. Our data show that the Fc αRI 844 A>G polymorphism is not associated with SSc or RA susceptibility. The Journal of Rheumatology

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DO - 10.3899/jrheum.100427

M3 - Journal articles

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AN - SCOPUS:79952395833

SN - 0315-162X

VL - 38

SP - 446

EP - 449

JO - Journal of Rheumatology

JF - Journal of Rheumatology

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