The effects of vertical sleeve gastrectomy in rodents are ghrelin independent

Adam P. Chambers; Henriette Kirchner; Hilary E. Wilson-Perez; Jill A. Willency; John E. Hale; Bruce D. Gaylinn; Michael O. Thorner; Paul T. Pfluger; Jesus A. Gutierrez; Matthias H. Tschöp; Darleen A. Sandoval; Randy J. Seeley

doi:10.1053/j.gastro.2012.09.009

The effects of vertical sleeve gastrectomy in rodents are ghrelin independent

Adam P. Chambers^*
, Henriette Kirchner
, Hilary E. Wilson-Perez
, Jill A. Willency
, John E. Hale
, Bruce D. Gaylinn
, Michael O. Thorner
, Paul T. Pfluger
, Jesus A. Gutierrez
, Matthias H. Tschöp
, Darleen A. Sandoval
, Randy J. Seeley

^*Corresponding author for this work

Department of Internal Medicine I

University of Cincinnati
Translational Science and Technologies
Eli Lilly and Company
University of Virginia
Institute for Diabetes and Obesity
Technical University of Munich

127 Citations (Scopus)

Abstract

Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgeries for obesity. We studied circulating levels of acyl and desacyl ghrelin in rats after these surgeries. We found that blood levels of ghrelin were reduced after VSG, but not after Roux-en-Y gastric bypass, based on enzyme-linked immunosorbent assay and mass-spectrometry analyses. We compared the effects of VSG in ghrelin-deficient mice and wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance. We found that VSG produced comparable outcomes in each strain. Reduced ghrelin signaling therefore does not appear to be required for these effects of VSG.

Original language	English
Journal	Gastroenterology
Volume	144
Issue number	1
Pages (from-to)	50-52.e5
ISSN	0016-5085
DOIs	https://doi.org/10.1053/j.gastro.2012.09.009
Publication status	Published - 01.01.2013

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10.1053/j.gastro.2012.09.009

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title = "The effects of vertical sleeve gastrectomy in rodents are ghrelin independent",

abstract = "Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgeries for obesity. We studied circulating levels of acyl and desacyl ghrelin in rats after these surgeries. We found that blood levels of ghrelin were reduced after VSG, but not after Roux-en-Y gastric bypass, based on enzyme-linked immunosorbent assay and mass-spectrometry analyses. We compared the effects of VSG in ghrelin-deficient mice and wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance. We found that VSG produced comparable outcomes in each strain. Reduced ghrelin signaling therefore does not appear to be required for these effects of VSG.",

author = "Chambers, \{Adam P.\} and Henriette Kirchner and Wilson-Perez, \{Hilary E.\} and Willency, \{Jill A.\} and Hale, \{John E.\} and Gaylinn, \{Bruce D.\} and Thorner, \{Michael O.\} and Pfluger, \{Paul T.\} and Gutierrez, \{Jesus A.\} and Tsch{\"o}p, \{Matthias H.\} and Sandoval, \{Darleen A.\} and Seeley, \{Randy J.\}",

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doi = "10.1053/j.gastro.2012.09.009",

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T1 - The effects of vertical sleeve gastrectomy in rodents are ghrelin independent

AU - Chambers, Adam P.

AU - Kirchner, Henriette

AU - Wilson-Perez, Hilary E.

AU - Willency, Jill A.

AU - Hale, John E.

AU - Gaylinn, Bruce D.

AU - Thorner, Michael O.

AU - Pfluger, Paul T.

AU - Gutierrez, Jesus A.

AU - Tschöp, Matthias H.

AU - Sandoval, Darleen A.

AU - Seeley, Randy J.

PY - 2013/1/1

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N2 - Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgeries for obesity. We studied circulating levels of acyl and desacyl ghrelin in rats after these surgeries. We found that blood levels of ghrelin were reduced after VSG, but not after Roux-en-Y gastric bypass, based on enzyme-linked immunosorbent assay and mass-spectrometry analyses. We compared the effects of VSG in ghrelin-deficient mice and wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance. We found that VSG produced comparable outcomes in each strain. Reduced ghrelin signaling therefore does not appear to be required for these effects of VSG.

AB - Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgeries for obesity. We studied circulating levels of acyl and desacyl ghrelin in rats after these surgeries. We found that blood levels of ghrelin were reduced after VSG, but not after Roux-en-Y gastric bypass, based on enzyme-linked immunosorbent assay and mass-spectrometry analyses. We compared the effects of VSG in ghrelin-deficient mice and wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance. We found that VSG produced comparable outcomes in each strain. Reduced ghrelin signaling therefore does not appear to be required for these effects of VSG.

UR - https://www.scopus.com/pages/publications/84871344743

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DO - 10.1053/j.gastro.2012.09.009

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SN - 0016-5085

VL - 144

SP - 50-52.e5

JO - Gastroenterology

JF - Gastroenterology

IS - 1

ER -

The effects of vertical sleeve gastrectomy in rodents are ghrelin independent

Abstract

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