The effect of the COMT val(158)met polymorphism on neural correlates of semantic verbal fluency

Axel Krug; Valentin Markov; Abigail Sheldrick; Sören Krach; Andreas Jansen; Klaus Zerres; Thomas Eggermann; Tony Stöcker; N Jon Shah; Tilo Kircher

doi:10.1007/s00406-009-0010-8

The effect of the COMT val(158)met polymorphism on neural correlates of semantic verbal fluency

Axel Krug, Valentin Markov, Abigail Sheldrick, Sören Krach, Andreas Jansen, Klaus Zerres, Thomas Eggermann, Tony Stöcker, N Jon Shah, Tilo Kircher

Clinic of Psychiatry and Psychotherapy

University of Marburg

Abstract

Variation in the val(158)met polymorphism of the COMT gene has been found to be associated with cognitive performance. In functional neuroimaging studies, this dysfunction has been linked to signal changes in prefrontal areas. Given the complex modulation and functional heterogeneity of frontal lobe systems, further specification of COMT gene-related phenotypes differing in prefrontally mediated cognitive performance are of major interest. Eighty healthy individuals (54 men, 26 women; mean age 23.3 years) performed an overt semantic verbal fluency task while brain activation was measured with functional magnetic resonance imaging (fMRI). COMT val(158)met genotype was determined and correlated with brain activation measured with fMRI during the task. Although there were no differences in performance, brain activation in the left inferior frontal gyrus [Brodmann area 10] was positively correlated with the number of val alleles in the COMT gene. COMT val(158)met status modulates brain activation during the language production on a semantic level in an area related to executive functions.

Original language	English
Journal	European Archives of Psychiatry and Clinical Neuroscience
Volume	259
Issue number	8
Pages (from-to)	459-65
Number of pages	7
ISSN	0940-1334
DOIs	https://doi.org/10.1007/s00406-009-0010-8
Publication status	Published - 2009

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10.1007/s00406-009-0010-8

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title = "The effect of the COMT val(158)met polymorphism on neural correlates of semantic verbal fluency",

abstract = "Variation in the val(158)met polymorphism of the COMT gene has been found to be associated with cognitive performance. In functional neuroimaging studies, this dysfunction has been linked to signal changes in prefrontal areas. Given the complex modulation and functional heterogeneity of frontal lobe systems, further specification of COMT gene-related phenotypes differing in prefrontally mediated cognitive performance are of major interest. Eighty healthy individuals (54 men, 26 women; mean age 23.3 years) performed an overt semantic verbal fluency task while brain activation was measured with functional magnetic resonance imaging (fMRI). COMT val(158)met genotype was determined and correlated with brain activation measured with fMRI during the task. Although there were no differences in performance, brain activation in the left inferior frontal gyrus [Brodmann area 10] was positively correlated with the number of val alleles in the COMT gene. COMT val(158)met status modulates brain activation during the language production on a semantic level in an area related to executive functions.",

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doi = "10.1007/s00406-009-0010-8",

language = "English",

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journal = "European Archives of Psychiatry and Clinical Neuroscience",

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T1 - The effect of the COMT val(158)met polymorphism on neural correlates of semantic verbal fluency

AU - Krug, Axel

AU - Markov, Valentin

AU - Sheldrick, Abigail

AU - Krach, Sören

AU - Jansen, Andreas

AU - Zerres, Klaus

AU - Eggermann, Thomas

AU - Stöcker, Tony

AU - Shah, N Jon

AU - Kircher, Tilo

PY - 2009

Y1 - 2009

N2 - Variation in the val(158)met polymorphism of the COMT gene has been found to be associated with cognitive performance. In functional neuroimaging studies, this dysfunction has been linked to signal changes in prefrontal areas. Given the complex modulation and functional heterogeneity of frontal lobe systems, further specification of COMT gene-related phenotypes differing in prefrontally mediated cognitive performance are of major interest. Eighty healthy individuals (54 men, 26 women; mean age 23.3 years) performed an overt semantic verbal fluency task while brain activation was measured with functional magnetic resonance imaging (fMRI). COMT val(158)met genotype was determined and correlated with brain activation measured with fMRI during the task. Although there were no differences in performance, brain activation in the left inferior frontal gyrus [Brodmann area 10] was positively correlated with the number of val alleles in the COMT gene. COMT val(158)met status modulates brain activation during the language production on a semantic level in an area related to executive functions.

AB - Variation in the val(158)met polymorphism of the COMT gene has been found to be associated with cognitive performance. In functional neuroimaging studies, this dysfunction has been linked to signal changes in prefrontal areas. Given the complex modulation and functional heterogeneity of frontal lobe systems, further specification of COMT gene-related phenotypes differing in prefrontally mediated cognitive performance are of major interest. Eighty healthy individuals (54 men, 26 women; mean age 23.3 years) performed an overt semantic verbal fluency task while brain activation was measured with functional magnetic resonance imaging (fMRI). COMT val(158)met genotype was determined and correlated with brain activation measured with fMRI during the task. Although there were no differences in performance, brain activation in the left inferior frontal gyrus [Brodmann area 10] was positively correlated with the number of val alleles in the COMT gene. COMT val(158)met status modulates brain activation during the language production on a semantic level in an area related to executive functions.

U2 - 10.1007/s00406-009-0010-8

DO - 10.1007/s00406-009-0010-8

M3 - Journal articles

C2 - 19381707

SN - 0940-1334

VL - 259

SP - 459

EP - 465

JO - European Archives of Psychiatry and Clinical Neuroscience

JF - European Archives of Psychiatry and Clinical Neuroscience

IS - 8

ER -

The effect of the COMT val(158)met polymorphism on neural correlates of semantic verbal fluency

Abstract

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