The effect of less invasive surfactant administration on cerebral oxygenation in preterm infants

Kathrin Hanke; Tanja K. Rausch; Pia Paul; Isabel Hellwig; Christina Krämer; Guido Stichtenoth; Alexander Herz; Christian Wieg; Inke R. König; Wolfgang Göpel; Egbert Herting; Christoph Härtel

doi:10.1111/apa.14939

The effect of less invasive surfactant administration on cerebral oxygenation in preterm infants

Kathrin Hanke, Tanja K. Rausch, Pia Paul, Isabel Hellwig, Christina Krämer, Guido Stichtenoth, Alexander Herz, Christian Wieg, Inke R. König, Wolfgang Göpel, Egbert Herting, Christoph Härtel^*

^*Corresponding author for this work

Children's Hospital Aschaffenburg

16 Citations (Scopus)

Abstract

Aim: To determine the regional cerebral tissue oxygenation saturation (rcSO₂) in a group of infants requiring less invasive surfactant administration (LISA) as compared to infants with continuous positive airway pressure (CPAP) only. Methods: In preterm infants with a gestational age 26 0/7-31 6/7 weeks, we conducted an observational study using near-infrared spectroscopy (NIRS) in the first 120 hours of life. Results: We analysed the data of 22 infants who never received surfactant (CPAP), 22 infants had LISA and CPAP (LISA) and 6 infants received surfactant via endotracheal tube (ETT). Four infants had both surfactant application modes including six LISA applications. In total, there were 32 successful LISA applications but 44 attempts; 13/44 (30%) of LISA attempts resulted in a 20% decrease of rcSO₂. During the first 120 hours of life, rcSO₂ values of CPAP were similar to those of infants in the LISA group, that is median rcSO₂ values 90% vs 85%, respectively (P =.126). Episodes with rcSO₂ values <65% were 0.4% in the CPAP group as compared to 4.8% in the LISA group (P <.001). Conclusion: Our observational data indicate that rcSO₂ values of infants in the LISA group were similar to the CPAP group.

Original language	English
Journal	Acta Paediatrica, International Journal of Paediatrics
Volume	109
Issue number	2
Pages (from-to)	291-299
Number of pages	9
ISSN	0803-5253
DOIs	https://doi.org/10.1111/apa.14939
Publication status	Published - 01.02.2020

Funding

We are grateful to all nurses and physicians involved in this study, particularly our study nurse Irene Fischer. We are grateful to the infants and parents who supported our study.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 5 Gender Equality

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

Access to Document

10.1111/apa.14939

Cite this

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title = "The effect of less invasive surfactant administration on cerebral oxygenation in preterm infants",

abstract = "Aim: To determine the regional cerebral tissue oxygenation saturation (rcSO2) in a group of infants requiring less invasive surfactant administration (LISA) as compared to infants with continuous positive airway pressure (CPAP) only. Methods: In preterm infants with a gestational age 26 0/7-31 6/7 weeks, we conducted an observational study using near-infrared spectroscopy (NIRS) in the first 120 hours of life. Results: We analysed the data of 22 infants who never received surfactant (CPAP), 22 infants had LISA and CPAP (LISA) and 6 infants received surfactant via endotracheal tube (ETT). Four infants had both surfactant application modes including six LISA applications. In total, there were 32 successful LISA applications but 44 attempts; 13/44 (30\%) of LISA attempts resulted in a 20\% decrease of rcSO2. During the first 120 hours of life, rcSO2 values of CPAP were similar to those of infants in the LISA group, that is median rcSO2 values 90\% vs 85\%, respectively (P =.126). Episodes with rcSO2 values <65\% were 0.4\% in the CPAP group as compared to 4.8\% in the LISA group (P <.001). Conclusion: Our observational data indicate that rcSO2 values of infants in the LISA group were similar to the CPAP group.",

author = "Kathrin Hanke and Rausch, \{Tanja K.\} and Pia Paul and Isabel Hellwig and Christina Kr{\"a}mer and Guido Stichtenoth and Alexander Herz and Christian Wieg and K{\"o}nig, \{Inke R.\} and Wolfgang G{\"o}pel and Egbert Herting and Christoph H{\"a}rtel",

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T1 - The effect of less invasive surfactant administration on cerebral oxygenation in preterm infants

AU - Hanke, Kathrin

AU - Rausch, Tanja K.

AU - Paul, Pia

AU - Hellwig, Isabel

AU - Krämer, Christina

AU - Stichtenoth, Guido

AU - Herz, Alexander

AU - Wieg, Christian

AU - König, Inke R.

AU - Göpel, Wolfgang

AU - Herting, Egbert

AU - Härtel, Christoph

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Aim: To determine the regional cerebral tissue oxygenation saturation (rcSO2) in a group of infants requiring less invasive surfactant administration (LISA) as compared to infants with continuous positive airway pressure (CPAP) only. Methods: In preterm infants with a gestational age 26 0/7-31 6/7 weeks, we conducted an observational study using near-infrared spectroscopy (NIRS) in the first 120 hours of life. Results: We analysed the data of 22 infants who never received surfactant (CPAP), 22 infants had LISA and CPAP (LISA) and 6 infants received surfactant via endotracheal tube (ETT). Four infants had both surfactant application modes including six LISA applications. In total, there were 32 successful LISA applications but 44 attempts; 13/44 (30%) of LISA attempts resulted in a 20% decrease of rcSO2. During the first 120 hours of life, rcSO2 values of CPAP were similar to those of infants in the LISA group, that is median rcSO2 values 90% vs 85%, respectively (P =.126). Episodes with rcSO2 values <65% were 0.4% in the CPAP group as compared to 4.8% in the LISA group (P <.001). Conclusion: Our observational data indicate that rcSO2 values of infants in the LISA group were similar to the CPAP group.

AB - Aim: To determine the regional cerebral tissue oxygenation saturation (rcSO2) in a group of infants requiring less invasive surfactant administration (LISA) as compared to infants with continuous positive airway pressure (CPAP) only. Methods: In preterm infants with a gestational age 26 0/7-31 6/7 weeks, we conducted an observational study using near-infrared spectroscopy (NIRS) in the first 120 hours of life. Results: We analysed the data of 22 infants who never received surfactant (CPAP), 22 infants had LISA and CPAP (LISA) and 6 infants received surfactant via endotracheal tube (ETT). Four infants had both surfactant application modes including six LISA applications. In total, there were 32 successful LISA applications but 44 attempts; 13/44 (30%) of LISA attempts resulted in a 20% decrease of rcSO2. During the first 120 hours of life, rcSO2 values of CPAP were similar to those of infants in the LISA group, that is median rcSO2 values 90% vs 85%, respectively (P =.126). Episodes with rcSO2 values <65% were 0.4% in the CPAP group as compared to 4.8% in the LISA group (P <.001). Conclusion: Our observational data indicate that rcSO2 values of infants in the LISA group were similar to the CPAP group.

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The effect of less invasive surfactant administration on cerebral oxygenation in preterm infants

Abstract

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