Abstract
Carbamazepine treatment of a patient with 48-hour rapid cycling led to a dampening of mood cycling, and prolonged rapid eye movement (REM) sleep latency. No effect on central α-receptors as measured by growth hormone (GH) secretion after clonidine stimulation or on spontaneous 48-hour GH secretion was observed. In 12 healthy subjects given 400 mg carbamazepine daily for a period of 5 days, improved sleep continuity and increased slow-wave sleep occurred with treatment. REM sleep percentage and REM latency remained uninfluenced, whereas REM density decreased. GH secretion after clonidine stimulation was not altered. Data from the single-case longitudinal study emphasize that carbamazepine is effective in treating rapid-cycling affective psychosis. Furthermore, neuroendocrine and sleep EEG data from the study in healthy subjects indicate a different profile of action for carbamazepine compared to most other antidepressants or antimanic drugs.
Original language | English |
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Journal | Neuropsychobiology |
Volume | 27 |
Issue number | 3 |
Pages (from-to) | 163-170 |
Number of pages | 8 |
ISSN | 0302-282X |
DOIs | |
Publication status | Published - 1993 |
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)