The effect of carbamazepine on endocrine and sleep eeg variables in a patient with 48-hour rapid cycling, and healthy controls

Dieter Riemann*, Horst Gann, Fritz Hohagen, Marcel Bahro, Walter E. Müller, Mathias Berger

*Corresponding author for this work
26 Citations (Scopus)

Abstract

Carbamazepine treatment of a patient with 48-hour rapid cycling led to a dampening of mood cycling, and prolonged rapid eye movement (REM) sleep latency. No effect on central α-receptors as measured by growth hormone (GH) secretion after clonidine stimulation or on spontaneous 48-hour GH secretion was observed. In 12 healthy subjects given 400 mg carbamazepine daily for a period of 5 days, improved sleep continuity and increased slow-wave sleep occurred with treatment. REM sleep percentage and REM latency remained uninfluenced, whereas REM density decreased. GH secretion after clonidine stimulation was not altered. Data from the single-case longitudinal study emphasize that carbamazepine is effective in treating rapid-cycling affective psychosis. Furthermore, neuroendocrine and sleep EEG data from the study in healthy subjects indicate a different profile of action for carbamazepine compared to most other antidepressants or antimanic drugs.

Original languageEnglish
JournalNeuropsychobiology
Volume27
Issue number3
Pages (from-to)163-170
Number of pages8
ISSN0302-282X
DOIs
Publication statusPublished - 1993

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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