Background: Type VII collagen is essential for skin stability as highlighted by related skin blistering diseases.Results: A fusion protein comprising the cysteine-rich region and parts of the flanking domains forms a trimer upon oxidization.Conclusion: The cysteine-rich region is an N-terminal cystine knot with novel topology.Significance: The cystine knot is also found in type IX collagen, indicating a general principle.
|Title of host publication||Journal of Biological Chemistry|
|Number of pages||9|
|Publisher||American Society for Biochemistry and Molecular Biology Inc.|
|ISBN (Print)||1083-351X (Electronic)\r0021-9258 (Linking)|
|Publication status||Published - 21.02.2014|