Abstract
Background: Type VII collagen is essential for skin stability as highlighted by related skin blistering diseases.Results: A fusion protein comprising the cysteine-rich region and parts of the flanking domains forms a trimer upon oxidization.Conclusion: The cysteine-rich region is an N-terminal cystine knot with novel topology.Significance: The cystine knot is also found in type IX collagen, indicating a general principle.
| Original language | English |
|---|---|
| Title of host publication | Journal of Biological Chemistry |
| Number of pages | 9 |
| Publisher | American Society for Biochemistry and Molecular Biology Inc. |
| Publication date | 21.02.2014 |
| Pages | 4861-4869 |
| ISBN (Print) | 1083-351X (Electronic)\r0021-9258 (Linking) |
| DOIs | |
| Publication status | Published - 21.02.2014 |
