The Concept of Coupling in the Mammalian Circadian Clock Network

Violetta Pilorz, Mariana Astiz, Keno Ole Heinen, Oliver Rawashdeh, Henrik Oster*

*Corresponding author for this work
3 Citations (Scopus)


The circadian clock network regulates daily rhythms in mammalian physiology and behavior to optimally adapt the organism to the 24-h day/night cycle. A central pacemaker, the hypothalamic suprachiasmatic nucleus (SCN), coordinates subordinate cellular oscillators in the brain, as well as in peripheral organs to align with each other and external time. Stability and coordination of this vast network of cellular oscillators is achieved through different levels of coupling. Although coupling at the molecular level and across the SCN is well established and believed to define its function as pacemaker structure, the notion of coupling in other tissues and across the whole system is less well understood. In this review, we describe the different levels of coupling in the mammalian circadian clock system – from molecules to the whole organism. We highlight recent advances in gaining knowledge of the complex organization and function of circadian network regulation and its significance for the generation of stable but plastic intrinsic 24-h rhythms.

Original languageEnglish
JournalJournal of Molecular Biology
Issue number12
Pages (from-to)3618-3638
Number of pages21
Publication statusPublished - 29.05.2020

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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