Abstract
Complement activation generates the core effector protein C5a, a potent immune molecule that is linked to multiple inflammatory diseases. Two C5a receptors, C5aR1 (C5aR, CD88) and C5aR2 (C5L2, GPR77), mediate the biological activities of C5a. Although C5aR1 has broadly acknowledged proinflammatory roles, C5aR2 remains at the center of controversy, with existing findings supporting both immune-activating and immune-dampening functions. Recent progress has been made toward resolving these issues. Instead of being a pure recycler and sequester of C5a, C5aR2 is capable of mediating its own set of signaling events and through these events exerting significant immunomodulatory effects not only toward C5aR1 but also other pattern recognition receptors and innate immune systems, such as NLRP3 inflammasomes. This review highlights the existing knowns and unknowns concerning C5aR2 and provides a timely update on recent breakthroughs which are expected to have a substantial impact on future fundamental and translational C5aR2 research.
| Original language | English |
|---|---|
| Journal | Journal of Immunology |
| Volume | 202 |
| Issue number | 12 |
| Pages (from-to) | 3339-3348 |
| Number of pages | 10 |
| ISSN | 0022-1767 |
| DOIs | |
| Publication status | Published - 15.06.2019 |
Funding
*School of Biomedical Sciences, The University of Queensland, St. Lucia, Queensland 4072, Australia; and †National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 ORCIDs: 0000-0001-5924-2977 (X.X.L.); 0000-0002-9976-7396 (J.D.L.); 0000-0003-4196-1417 (C.K.); 0000-0003-1382-911X (T.M.W.). This work was supported by National Health and Medical Research Council of Australia (NHMRC) Grant APP1082271. T.M.W. is supported by NHMRC Career Development Fellowship APP1105420.
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
