Abstract
In mammals, the master clock of the suprachiasmatic nuclei (SCN) and subordinate clocks found throughout the body coordinate circadian rhythms of behavior and physiology. We characterize the clock of the adrenal, an important endocrine gland that synchronizes physiological and metabolic rhythms. Clock gene expression was detected in the outer adrenal cortex prefiguring a role of the clock in regulating gluco- and mineral corticoid biogenesis. In Per2/Cry1 double mutant mice, which lack a circadian clock, hypothalamus/pituitary/adrenal axis regulation was defective. Organ culture and tissue transplantation suggest that the adrenal pacemaker gates glucocorticoid production in response to adrenocorticotropin (ACTH). In vivo the adrenal circadian clock can be entrained by light. Transcriptome profiling identified rhythmically expressed genes located at diverse nodes of steroid biogenesis that may mediate gating of the ACTH response by the adrenal clock.
| Original language | English |
|---|---|
| Journal | Cell Metabolism |
| Volume | 4 |
| Issue number | 2 |
| Pages (from-to) | 163-173 |
| Number of pages | 11 |
| ISSN | 1550-4131 |
| DOIs | |
| Publication status | Published - 01.08.2006 |
Funding
The authors thank Dr. G.T.J. van der Horst for the gift of Cry1 mutant mice, Dr. M. Straume for providing the COSOPT analysis software, and Dr. U. Albrecht for donating the template for the Per3 in situ probe and for critical comments on the manuscript. This work was supported by the EU grant QLG3-CT-2002-01829 and the Max-Planck-Society.
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
