The challenges and impact of microvascular injury in ST-elevation myocardial infarction

Sebastian Johannes Reinstadler, Thomas Stiermaier, Georg Fuernau, Suzanne De Waha, Steffen Desch, Bernhard Metzler, Holger Thiele, Ingo Eitel*

*Corresponding author for this work
8 Citations (Scopus)


Despite successful restoration of epicardial coronary blood flow, a significant proportion of patients with ST-elevation myocardial infarction suffer from an impairment of the microvascular perfusion-a phenomenon termed no-reflow or microvascular injury (MVI). The underlying pathophysiology is complex and likely multifactorial. It is well established that MVI is associated with worse clinical outcome. Although MVI can be detected during coronary intervention and the post-infarction period, its prevention and treatment strategies remain a major challenge since most results of clinical studies have been disappointing so far. This review provides an overview on the main pathophysiological mechanisms of MVI and its diagnostic approaches. Moreover, it will discuss its clinical consequences and current strategies of prevention and treatment.

Original languageEnglish
JournalExpert Review of Cardiovascular Therapy
Issue number4
Pages (from-to)431-443
Number of pages13
Publication statusPublished - 02.04.2016

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


Dive into the research topics of 'The challenges and impact of microvascular injury in ST-elevation myocardial infarction'. Together they form a unique fingerprint.

Cite this