TY - JOUR
T1 - The biology of burn injury
AU - Evers, Lars H.
AU - Bhavsar, Dhaval
AU - Mailänder, Peter
PY - 2010/9/1
Y1 - 2010/9/1
N2 - Burn injury is a complex traumatic event with various local and systemic effects, affecting several organ systems beyond the skin. The pathophysiology of the burn patient shows the full spectrum of the complexity of inflammatory response reactions. In the acute phase, inflammation mechanism may have negative effects because of capillary leak, the propagation of inhalation injury and the development of multiple organ failure. Attempts to mediate these processes remain a central subject of burn care research. Conversely, inflammation is a necessary prologue and component in the later-stage processes of wound healing. In this review, we are attempting to present the current science of burn wound pathophysiology and wound healing. We also describe the evolution of innovative strategies for burn management.
AB - Burn injury is a complex traumatic event with various local and systemic effects, affecting several organ systems beyond the skin. The pathophysiology of the burn patient shows the full spectrum of the complexity of inflammatory response reactions. In the acute phase, inflammation mechanism may have negative effects because of capillary leak, the propagation of inhalation injury and the development of multiple organ failure. Attempts to mediate these processes remain a central subject of burn care research. Conversely, inflammation is a necessary prologue and component in the later-stage processes of wound healing. In this review, we are attempting to present the current science of burn wound pathophysiology and wound healing. We also describe the evolution of innovative strategies for burn management.
UR - http://www.scopus.com/inward/record.url?scp=77955757186&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0625.2010.01105.x
DO - 10.1111/j.1600-0625.2010.01105.x
M3 - Scientific review articles
C2 - 20629737
AN - SCOPUS:77955757186
SN - 0906-6705
VL - 19
SP - 777
EP - 783
JO - Experimental Dermatology
JF - Experimental Dermatology
IS - 9
ER -