The basis of gender assignment in disorders of somatosexual differentiation

Olaf Hiort*, Ute Thyen, Paul Martin Holterhus

*Corresponding author for this work
14 Citations (Scopus)

Abstract

Sex assignment of patients with disorders of somatosexual differentiation is a controversial topic. The aim is to enable the patient to develop a stable gender identity during childhood, adolescence and adulthood. Enormous advances have recently been made in our knowledge of the molecular mechanisms of sexual differentiation and it is understood that long-term outcome may depend on the underlying diagnosis. There is increasing evidence that genital development is dependent on the action of androgenic steroids; moreover, both androgens and oestrogens may have an impact on other developing organs including neuronal structures such as the brain. Long-term outcome studies on the various intersexuality disorders are desperately needed in order to establish a basis for evidence-based medicine regarding sex assignment and treatment options. Premature decisions leading to irreversible interventions before an accurate diagnosis has been established must be avoided.

Original languageEnglish
JournalHormone Research
Volume64
Issue numberSUPPL. 2
Pages (from-to)18-22
Number of pages5
ISSN0301-0163
DOIs
Publication statusPublished - 11.2005

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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