The association between the antineoplastic drug daunomycin and iron. evidence for polynuclear aggregates

B. F. Matzanke; E. Bill; H. Winkler; A. X. Trautwein

doi:10.1007/BF02397313

The association between the antineoplastic drug daunomycin and iron. evidence for polynuclear aggregates

B. F. Matzanke^*, E. Bill, H. Winkler, A. X. Trautwein

^*Corresponding author for this work

Institute of Physics

University of Tubingen

2 Citations (Scopus)

Abstract

In contrast to literature data, at millimolar iron and daunomycin (DN) concentrations no solitary Fe(DN)₃ complexes are formed in appreciable amounts. The Mössbauer spectroscopic analysis revealed severe dependencies on temperature and on the metal ligand ratio. Two species can be discerned: exchange-coupled polynuclear aggregates, which are magnetically highly anisotropic and another superparamagnetic system, exhibiting much less magnetic anisotropy. The cooperative phenomena observed are attributed to stacking effects of daunomycin.

Original language	English
Journal	Hyperfine Interactions
Volume	71
Issue number	1-4
Pages (from-to)	1263-1266
Number of pages	4
ISSN	0304-3843
DOIs	https://doi.org/10.1007/BF02397313
Publication status	Published - 01.04.1992

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abstract = "In contrast to literature data, at millimolar iron and daunomycin (DN) concentrations no solitary Fe(DN)3 complexes are formed in appreciable amounts. The M{\"o}ssbauer spectroscopic analysis revealed severe dependencies on temperature and on the metal ligand ratio. Two species can be discerned: exchange-coupled polynuclear aggregates, which are magnetically highly anisotropic and another superparamagnetic system, exhibiting much less magnetic anisotropy. The cooperative phenomena observed are attributed to stacking effects of daunomycin.",

author = "Matzanke, {B. F.} and E. Bill and H. Winkler and Trautwein, {A. X.}",

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AU - Matzanke, B. F.

AU - Bill, E.

AU - Winkler, H.

AU - Trautwein, A. X.

PY - 1992/4/1

Y1 - 1992/4/1

N2 - In contrast to literature data, at millimolar iron and daunomycin (DN) concentrations no solitary Fe(DN)3 complexes are formed in appreciable amounts. The Mössbauer spectroscopic analysis revealed severe dependencies on temperature and on the metal ligand ratio. Two species can be discerned: exchange-coupled polynuclear aggregates, which are magnetically highly anisotropic and another superparamagnetic system, exhibiting much less magnetic anisotropy. The cooperative phenomena observed are attributed to stacking effects of daunomycin.

AB - In contrast to literature data, at millimolar iron and daunomycin (DN) concentrations no solitary Fe(DN)3 complexes are formed in appreciable amounts. The Mössbauer spectroscopic analysis revealed severe dependencies on temperature and on the metal ligand ratio. Two species can be discerned: exchange-coupled polynuclear aggregates, which are magnetically highly anisotropic and another superparamagnetic system, exhibiting much less magnetic anisotropy. The cooperative phenomena observed are attributed to stacking effects of daunomycin.

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JO - Hyperfine Interactions

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ER -

The association between the antineoplastic drug daunomycin and iron. evidence for polynuclear aggregates

Abstract

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