Temporary blast reduction after immunoglobulin administration for congenital cytomegalovirus infection masking infant leukemia with cryptic MLL rearrangement

Markus Metzler; Jochen Bruch; Daniel Stachel; Thorsten Langer; Arndt Borkhardt; Jochen Harbott; Wolfgang Rascher; Wolfgang Holter

doi:10.1016/j.leukres.2006.05.020

Temporary blast reduction after immunoglobulin administration for congenital cytomegalovirus infection masking infant leukemia with cryptic MLL rearrangement

Markus Metzler^*, Jochen Bruch, Daniel Stachel, Thorsten Langer, Arndt Borkhardt, Jochen Harbott, Wolfgang Rascher, Wolfgang Holter

^*Corresponding author for this work

Clinic of Pediatric and Adolescent Medicine

Abstract

Differentiation between reactive bone marrow suppression due to viral infection and early stages of leukemia can be difficult particularly in young infants. We report on a 2-month-old girl presenting with pancytopenia and positive markers for congenital cytomegalovirus (CMV) infection. Definitive diagnosis of coexisting pro-B cell infant leukemia with cryptic MLL rearrangement was delayed by the transient regeneration of normal hematopoiesis and reduction of abnormal blastoid cells in the bone marrow following immunoglobulin administration. Molecular diagnosis could only be established using interphase fluorescence in situ hybridization (FISH) analysis which may be considered as a valuable additional diagnostic tool in similar cases.

Original language	English
Journal	Leukemia Research
Volume	31
Issue number	4
Pages (from-to)	553-557
Number of pages	5
ISSN	0145-2126
DOIs	https://doi.org/10.1016/j.leukres.2006.05.020
Publication status	Published - 04.2007

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1016/j.leukres.2006.05.020

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title = "Temporary blast reduction after immunoglobulin administration for congenital cytomegalovirus infection masking infant leukemia with cryptic MLL rearrangement",

abstract = "Differentiation between reactive bone marrow suppression due to viral infection and early stages of leukemia can be difficult particularly in young infants. We report on a 2-month-old girl presenting with pancytopenia and positive markers for congenital cytomegalovirus (CMV) infection. Definitive diagnosis of coexisting pro-B cell infant leukemia with cryptic MLL rearrangement was delayed by the transient regeneration of normal hematopoiesis and reduction of abnormal blastoid cells in the bone marrow following immunoglobulin administration. Molecular diagnosis could only be established using interphase fluorescence in situ hybridization (FISH) analysis which may be considered as a valuable additional diagnostic tool in similar cases.",

author = "Markus Metzler and Jochen Bruch and Daniel Stachel and Thorsten Langer and Arndt Borkhardt and Jochen Harbott and Wolfgang Rascher and Wolfgang Holter",

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T1 - Temporary blast reduction after immunoglobulin administration for congenital cytomegalovirus infection masking infant leukemia with cryptic MLL rearrangement

AU - Metzler, Markus

AU - Bruch, Jochen

AU - Stachel, Daniel

AU - Langer, Thorsten

AU - Borkhardt, Arndt

AU - Harbott, Jochen

AU - Rascher, Wolfgang

AU - Holter, Wolfgang

PY - 2007/4

Y1 - 2007/4

N2 - Differentiation between reactive bone marrow suppression due to viral infection and early stages of leukemia can be difficult particularly in young infants. We report on a 2-month-old girl presenting with pancytopenia and positive markers for congenital cytomegalovirus (CMV) infection. Definitive diagnosis of coexisting pro-B cell infant leukemia with cryptic MLL rearrangement was delayed by the transient regeneration of normal hematopoiesis and reduction of abnormal blastoid cells in the bone marrow following immunoglobulin administration. Molecular diagnosis could only be established using interphase fluorescence in situ hybridization (FISH) analysis which may be considered as a valuable additional diagnostic tool in similar cases.

AB - Differentiation between reactive bone marrow suppression due to viral infection and early stages of leukemia can be difficult particularly in young infants. We report on a 2-month-old girl presenting with pancytopenia and positive markers for congenital cytomegalovirus (CMV) infection. Definitive diagnosis of coexisting pro-B cell infant leukemia with cryptic MLL rearrangement was delayed by the transient regeneration of normal hematopoiesis and reduction of abnormal blastoid cells in the bone marrow following immunoglobulin administration. Molecular diagnosis could only be established using interphase fluorescence in situ hybridization (FISH) analysis which may be considered as a valuable additional diagnostic tool in similar cases.

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U2 - 10.1016/j.leukres.2006.05.020

DO - 10.1016/j.leukres.2006.05.020

M3 - Journal articles

C2 - 16814860

AN - SCOPUS:33846809472

SN - 0145-2126

VL - 31

SP - 553

EP - 557

JO - Leukemia Research

JF - Leukemia Research

IS - 4

ER -

Temporary blast reduction after immunoglobulin administration for congenital cytomegalovirus infection masking infant leukemia with cryptic MLL rearrangement

Abstract

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