Target evaluation processing and serum levels of nerve tissue protein S100B in patients with remitted major depression

Detlef E. Dietrich; Ute Hauser; Marion Peters; Yuanyuan Zhang; Martin Wiesmann; Mark Hasselmann; Sebastian Rudolf; Oliver Jüngling; Holger Kirchner; Thomas F. Münte; Volker Arolt; Hinderk M. Emrich; Sönke Johannes; Matthias Rothermundt

doi:10.1016/j.neulet.2003.09.062

Target evaluation processing and serum levels of nerve tissue protein S100B in patients with remitted major depression

Detlef E. Dietrich^*, Ute Hauser, Marion Peters, Yuanyuan Zhang, Martin Wiesmann, Mark Hasselmann, Sebastian Rudolf, Oliver Jüngling, Holger Kirchner, Thomas F. Münte, Volker Arolt, Hinderk M. Emrich, Sönke Johannes, Matthias Rothermundt

^*Corresponding author for this work

Department of Neurology

31 Citations (Scopus)

Abstract

Selective attention processes (N2 and P3 components of event-related potentials (ERPs)) have been shown to be impaired in depressed patients but findings have been mixed. Part of this variability might be explained by neurobiological factors. ERPs (Go/Nogo paradigm) were investigated in patients with remitted major depression in relation to S100B. S100B, an astroglial protein with neuroplastic properties, has been shown to be increased in depression. Its pathophysiologic role in depression, however, is not yet sufficiently understood. Patients with increased S100B serum levels (n=6) showed a normal N2- and P3-amplitude in contrast to a reduced N2- and P3-amplitude in patients with normal S100B serum levels (n=6). These findings provide evidence of a correlation between S100B levels and attentional processes in patients with recurrent depression and further substantiate S100B's role as a marker in the course of affective disorders.

Original language	English
Journal	Neuroscience Letters
Volume	354
Issue number	1
Pages (from-to)	69-73
Number of pages	5
ISSN	0304-3940
DOIs	https://doi.org/10.1016/j.neulet.2003.09.062
Publication status	Published - 02.01.2004

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SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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Dietrich, D. E., Hauser, U., Peters, M., Zhang, Y., Wiesmann, M., Hasselmann, M., Rudolf, S., Jüngling, O., Kirchner, H., Münte, T. F., Arolt, V., Emrich, H. M., Johannes, S., & Rothermundt, M. (2004). Target evaluation processing and serum levels of nerve tissue protein S100B in patients with remitted major depression. Neuroscience Letters, 354(1), 69-73. https://doi.org/10.1016/j.neulet.2003.09.062

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abstract = "Selective attention processes (N2 and P3 components of event-related potentials (ERPs)) have been shown to be impaired in depressed patients but findings have been mixed. Part of this variability might be explained by neurobiological factors. ERPs (Go/Nogo paradigm) were investigated in patients with remitted major depression in relation to S100B. S100B, an astroglial protein with neuroplastic properties, has been shown to be increased in depression. Its pathophysiologic role in depression, however, is not yet sufficiently understood. Patients with increased S100B serum levels (n=6) showed a normal N2- and P3-amplitude in contrast to a reduced N2- and P3-amplitude in patients with normal S100B serum levels (n=6). These findings provide evidence of a correlation between S100B levels and attentional processes in patients with recurrent depression and further substantiate S100B's role as a marker in the course of affective disorders.",

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Dietrich, DE, Hauser, U, Peters, M, Zhang, Y, Wiesmann, M, Hasselmann, M, Rudolf, S, Jüngling, O, Kirchner, H, Münte, TF, Arolt, V, Emrich, HM, Johannes, S & Rothermundt, M 2004, 'Target evaluation processing and serum levels of nerve tissue protein S100B in patients with remitted major depression', Neuroscience Letters, vol. 354, no. 1, pp. 69-73. https://doi.org/10.1016/j.neulet.2003.09.062

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T1 - Target evaluation processing and serum levels of nerve tissue protein S100B in patients with remitted major depression

AU - Dietrich, Detlef E.

AU - Hauser, Ute

AU - Peters, Marion

AU - Zhang, Yuanyuan

AU - Wiesmann, Martin

AU - Hasselmann, Mark

AU - Rudolf, Sebastian

AU - Jüngling, Oliver

AU - Kirchner, Holger

AU - Münte, Thomas F.

AU - Arolt, Volker

AU - Emrich, Hinderk M.

AU - Johannes, Sönke

AU - Rothermundt, Matthias

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N2 - Selective attention processes (N2 and P3 components of event-related potentials (ERPs)) have been shown to be impaired in depressed patients but findings have been mixed. Part of this variability might be explained by neurobiological factors. ERPs (Go/Nogo paradigm) were investigated in patients with remitted major depression in relation to S100B. S100B, an astroglial protein with neuroplastic properties, has been shown to be increased in depression. Its pathophysiologic role in depression, however, is not yet sufficiently understood. Patients with increased S100B serum levels (n=6) showed a normal N2- and P3-amplitude in contrast to a reduced N2- and P3-amplitude in patients with normal S100B serum levels (n=6). These findings provide evidence of a correlation between S100B levels and attentional processes in patients with recurrent depression and further substantiate S100B's role as a marker in the course of affective disorders.

AB - Selective attention processes (N2 and P3 components of event-related potentials (ERPs)) have been shown to be impaired in depressed patients but findings have been mixed. Part of this variability might be explained by neurobiological factors. ERPs (Go/Nogo paradigm) were investigated in patients with remitted major depression in relation to S100B. S100B, an astroglial protein with neuroplastic properties, has been shown to be increased in depression. Its pathophysiologic role in depression, however, is not yet sufficiently understood. Patients with increased S100B serum levels (n=6) showed a normal N2- and P3-amplitude in contrast to a reduced N2- and P3-amplitude in patients with normal S100B serum levels (n=6). These findings provide evidence of a correlation between S100B levels and attentional processes in patients with recurrent depression and further substantiate S100B's role as a marker in the course of affective disorders.

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Target evaluation processing and serum levels of nerve tissue protein S100B in patients with remitted major depression

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