TY - JOUR
T1 - Tanycytes in the infundibular nucleus and median eminence and their role in the blood-brain barrier
AU - Prevot, Vincent
AU - Nogueiras, Ruben
AU - Schwaninger, Markus
N1 - Copyright © 2021 Elsevier B.V. All rights reserved.
PY - 2021
Y1 - 2021
N2 - The blood-brain barrier is generally attributed to endothelial cells. However, in circumventricular organs, such as the median eminence, tanycytes take over the barrier function. These ependymoglial cells form the wall of the third ventricle and send long extensions into the parenchyma to contact blood vessels and hypothalamic neurons. The shape and location of tanycytes put them in an ideal position to connect the periphery with central nervous compartments. In line with this, tanycytes control the transport of hormones and key metabolites in and out of the hypothalamus. They function as sensors of peripheral homeostasis for central regulatory networks. This chapter discusses current evidence that tanycytes play a key role in regulating glucose balance, food intake, endocrine axes, seasonal changes, reproductive function, and aging. The understanding of how tanycytes perform these diverse tasks is only just beginning to emerge and will probably lead to a more differentiated view of how the brain and the periphery interact.
AB - The blood-brain barrier is generally attributed to endothelial cells. However, in circumventricular organs, such as the median eminence, tanycytes take over the barrier function. These ependymoglial cells form the wall of the third ventricle and send long extensions into the parenchyma to contact blood vessels and hypothalamic neurons. The shape and location of tanycytes put them in an ideal position to connect the periphery with central nervous compartments. In line with this, tanycytes control the transport of hormones and key metabolites in and out of the hypothalamus. They function as sensors of peripheral homeostasis for central regulatory networks. This chapter discusses current evidence that tanycytes play a key role in regulating glucose balance, food intake, endocrine axes, seasonal changes, reproductive function, and aging. The understanding of how tanycytes perform these diverse tasks is only just beginning to emerge and will probably lead to a more differentiated view of how the brain and the periphery interact.
U2 - 10.1016/B978-0-12-820107-7.00016-1
DO - 10.1016/B978-0-12-820107-7.00016-1
M3 - Scientific review articles
C2 - 34225934
SN - 0072-9752
VL - 180
SP - 253
EP - 273
JO - Handbook of Clinical Neurology
JF - Handbook of Clinical Neurology
ER -