Tandem RCM-lsomerization-cyclopropanation reactions

Álvaro Mallagaray, Gema Domínguez, Ana Gradillas, Javier Pérez-Castells*

*Corresponding author for this work
37 Citations (Scopus)


A new triple tandem process has been discovered in which simple acyclic substrates can be transformed into bicyclic compounds via RCMdouble bond isomerization-cyclopropanation. This process is catalyzed by second generation Grubb's catalyst without the requirement of other reactives or additives. In addition, a one-pot RCM-isomerization reaction followed by cyclopropanation with CHCl3/NaOH allows the synthesis of products related to iNOS (nitric oxide synthase) inhibitors, which are currently under clinical evaluation.

Original languageEnglish
JournalOrganic Letters
Issue number4
Pages (from-to)597-600
Number of pages4
Publication statusPublished - 21.02.2008

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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