Tactile Vision, Epistemic Things and Data Visualization**

Hans-Jörg Rheinberger constructed his historical epistemology of epistemic things by analyzing experimental practices in molecular biology during the 1970s and 80s. With genetic sequencing and multi-omics approaches, data has become a new resource in the life sciences, questioning the applicability of his concept of experimental system. By historicizing Rheinberger's epistemology, the paper focuses on its relatedness to Ludwik Fleck's notion of an aviso of resistance and points to a gradual shift in Rheinberger's emphasis, moving from an initial focus on writing and its differentiality to work on materials, preparations, and representations. By anchoring visualization in these material practices, Rheinberger also sheds new light on the changing conditions of experimentation in the life sciences due to big data, where visualization emphasizes patterns and correlations rather than substrates.