T-cell regulation: With complements from innate immunity

Claudia Kemper, John P. Atkinson*

*Corresponding author for this work
256 Citations (Scopus)


The complement system was traditionally known as an effector arm of humoral immunity. Today we also recognize it as a main element of the innate immune system. In blood and other body fluids complement is a first line of defence against pathogens, because it becomes fully active within seconds. Active complement fragments attach to the invading pathogen to promote opsonization and lysis, triggering a local inflammatory response. This Review focuses on the evolving role of the complement system in the regulation of T-cell responses, from directing the initiation phase, through driving lineage commitment, to regulating the contraction phase.

Original languageEnglish
JournalNature Reviews Immunology
Issue number1
Pages (from-to)9-18
Number of pages10
Publication statusPublished - 01.2007

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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