Systematic review of Mendelian randomization studies on Parkinson's disease

Sophia Kappen; Daniele Bottigliengo; Amke Caliebe; Fabiola M. Del Greco; Inke R. König

doi:10.1515/medgen-2022-2139

Systematic review of Mendelian randomization studies on Parkinson's disease

Sophia Kappen, Daniele Bottigliengo, Amke Caliebe, Fabiola M. Del Greco^*, Inke R. König^*

^*Corresponding author for this work

Institute of Medical Biometry and Statistic

University of Kiel

Abstract

Background: Parkinson's disease (PD) is known to be associated with non-genetic factors. To infer causality, Mendelian randomization (MR) studies are increasingly used. Here, genetic variants are used as instrumental variables for the risk factor but have no direct effect on PD themselves. Methods: We performed a systematic literature review on MR studies for PD. Studies were identified searching the PubMed database. Upon data extraction, we evaluated the methodological quality and summarized the evidence. Results: Twelve articles were included. Most studies showed "good"methodological quality, but most did not report proper power estimations. Twelve analyses yielded nominally significant effects. Conclusions: Our systematic review shows that most MR studies were well performed and allow to identify causal exposures, which may inform further studies on the prevention and early intervention of PD.

Original language	English
Journal	Medizinische Genetik
Volume	34
Issue number	2
Pages (from-to)	143-150
Number of pages	8
ISSN	0936-5931
DOIs	https://doi.org/10.1515/medgen-2022-2139
Publication status	Published - 01.06.2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1515/medgen-2022-2139

Cite this

@article{5a00b19bec5845deb855f9b601fa770f,

title = "Systematic review of Mendelian randomization studies on Parkinson's disease",

abstract = "Background: Parkinson's disease (PD) is known to be associated with non-genetic factors. To infer causality, Mendelian randomization (MR) studies are increasingly used. Here, genetic variants are used as instrumental variables for the risk factor but have no direct effect on PD themselves. Methods: We performed a systematic literature review on MR studies for PD. Studies were identified searching the PubMed database. Upon data extraction, we evaluated the methodological quality and summarized the evidence. Results: Twelve articles were included. Most studies showed {"}good{"}methodological quality, but most did not report proper power estimations. Twelve analyses yielded nominally significant effects. Conclusions: Our systematic review shows that most MR studies were well performed and allow to identify causal exposures, which may inform further studies on the prevention and early intervention of PD.",

author = "Sophia Kappen and Daniele Bottigliengo and Amke Caliebe and {Del Greco}, {Fabiola M.} and K{\"o}nig, {Inke R.}",

note = "Publisher Copyright: {\textcopyright} 2022 the author(s), published by De Gruyter.",

year = "2022",

month = jun,

day = "1",

doi = "10.1515/medgen-2022-2139",

language = "English",

volume = "34",

pages = "143--150",

journal = "Medizinische Genetik",

issn = "0936-5931",

number = "2",

}

TY - JOUR

T1 - Systematic review of Mendelian randomization studies on Parkinson's disease

AU - Kappen, Sophia

AU - Bottigliengo, Daniele

AU - Caliebe, Amke

AU - Del Greco, Fabiola M.

AU - König, Inke R.

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Background: Parkinson's disease (PD) is known to be associated with non-genetic factors. To infer causality, Mendelian randomization (MR) studies are increasingly used. Here, genetic variants are used as instrumental variables for the risk factor but have no direct effect on PD themselves. Methods: We performed a systematic literature review on MR studies for PD. Studies were identified searching the PubMed database. Upon data extraction, we evaluated the methodological quality and summarized the evidence. Results: Twelve articles were included. Most studies showed "good"methodological quality, but most did not report proper power estimations. Twelve analyses yielded nominally significant effects. Conclusions: Our systematic review shows that most MR studies were well performed and allow to identify causal exposures, which may inform further studies on the prevention and early intervention of PD.

AB - Background: Parkinson's disease (PD) is known to be associated with non-genetic factors. To infer causality, Mendelian randomization (MR) studies are increasingly used. Here, genetic variants are used as instrumental variables for the risk factor but have no direct effect on PD themselves. Methods: We performed a systematic literature review on MR studies for PD. Studies were identified searching the PubMed database. Upon data extraction, we evaluated the methodological quality and summarized the evidence. Results: Twelve articles were included. Most studies showed "good"methodological quality, but most did not report proper power estimations. Twelve analyses yielded nominally significant effects. Conclusions: Our systematic review shows that most MR studies were well performed and allow to identify causal exposures, which may inform further studies on the prevention and early intervention of PD.

UR - http://www.scopus.com/inward/record.url?scp=85135940026&partnerID=8YFLogxK

U2 - 10.1515/medgen-2022-2139

DO - 10.1515/medgen-2022-2139

M3 - Scientific review articles

AN - SCOPUS:85135940026

SN - 0936-5931

VL - 34

SP - 143

EP - 150

JO - Medizinische Genetik

JF - Medizinische Genetik

IS - 2

ER -

Systematic review of Mendelian randomization studies on Parkinson's disease

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this